Hemophagocytic syndrome secondary to cavitary pulmonary tuberculosis

Hemophagocytic syndrome is due to the activation and nonmalignant proliferation of macrophages and T lymphocytes. The purpose of this report is to describe a 25-year-old man who presented with fever, coughing, and weight loss over the past month. Laboratory findings demonstrated pancytopenia, hyperf...

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Vydáno v:Médecine et santé tropicales (Montrouge, France) Ročník 22; číslo 1; s. 99
Hlavní autoři: Rakotoson, J L, Rakotonirainy, O H, Moroyandsa, F, Rakotoharivelo, H, Rakotomizao, J R, Andrianarisoa, A C F
Médium: Journal Article
Jazyk:francouzština
Vydáno: France 01.01.2012
Témata:
Adult
Humans
Lymphohistiocytosis, Hemophagocytic - etiology
Male
Tuberculosis, Pulmonary - complications
ISSN:2261-2211, 2261-2211
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Popis
Shrnutí:Hemophagocytic syndrome is due to the activation and nonmalignant proliferation of macrophages and T lymphocytes. The purpose of this report is to describe a 25-year-old man who presented with fever, coughing, and weight loss over the past month. Laboratory findings demonstrated pancytopenia, hyperferritinemia, and cytolysis. The myelogram showed a hemophagocytic syndrome, and tuberculosis bacilli were found in the sputum. Chest radiography and thoracic computed tomography depicted a cavitary lesion suggestive of pulmonary tuberculosis. Treatment of tuberculosis alone, without an immunosuppressant agent, was effective and led to improvement. In a country where tuberculosis is highly endemic, hemophagocytic syndrome should be considered in the differential diagnosis of patients with active tuberculosis complicated by pancytopenia.
Bibliografie:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Correspondence-5
ObjectType-Article-4
ObjectType-Report-1
ISSN:2261-2211
2261-2211
DOI:10.1684/mst.2012.0020