Hemophagocytic syndrome secondary to cavitary pulmonary tuberculosis

Hemophagocytic syndrome is due to the activation and nonmalignant proliferation of macrophages and T lymphocytes. The purpose of this report is to describe a 25-year-old man who presented with fever, coughing, and weight loss over the past month. Laboratory findings demonstrated pancytopenia, hyperf...

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Bibliographic Details
Published in:Médecine et santé tropicales (Montrouge, France) Vol. 22; no. 1; p. 99
Main Authors: Rakotoson, J L, Rakotonirainy, O H, Moroyandsa, F, Rakotoharivelo, H, Rakotomizao, J R, Andrianarisoa, A C F
Format: Journal Article
Language:French
Published: France 01.01.2012
Subjects:
Adult
Humans
Lymphohistiocytosis, Hemophagocytic - etiology
Male
Tuberculosis, Pulmonary - complications
ISSN:2261-2211, 2261-2211
Online Access:Get more information
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Summary:Hemophagocytic syndrome is due to the activation and nonmalignant proliferation of macrophages and T lymphocytes. The purpose of this report is to describe a 25-year-old man who presented with fever, coughing, and weight loss over the past month. Laboratory findings demonstrated pancytopenia, hyperferritinemia, and cytolysis. The myelogram showed a hemophagocytic syndrome, and tuberculosis bacilli were found in the sputum. Chest radiography and thoracic computed tomography depicted a cavitary lesion suggestive of pulmonary tuberculosis. Treatment of tuberculosis alone, without an immunosuppressant agent, was effective and led to improvement. In a country where tuberculosis is highly endemic, hemophagocytic syndrome should be considered in the differential diagnosis of patients with active tuberculosis complicated by pancytopenia.
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ISSN:2261-2211
2261-2211
DOI:10.1684/mst.2012.0020