Experimental approach to the prophylaxis and treatment of acute lung injury syndrome with proteinase inhibitors and corvitin

The results of a combined study of the proteolysis on a model of post-ischemic toxemia in rats showed a decrease in antiproteinase potential and an activation of proteolysis. The activation of proteolysis and inhibition of antiproteinases was observed not only in the blood, but also in the bronchoal...

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Published in:Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) Vol. 49; no. 4; p. 63
Main Authors: Moĭbenko, O O, Kubyshkin, A V, Kharchenko, V Z, Horokhova, N Iu, Semenets', P F
Format: Journal Article
Language:Ukrainian
Published: Ukraine 2003
Subjects:
Animals
Aprotinin - therapeutic use
Bronchoalveolar Lavage Fluid - cytology
Disease Models, Animal
Drug Therapy, Combination
Endopeptidases - blood
Endopeptidases - metabolism
Flavonoids - administration & dosage
Flavonoids - therapeutic use
Lung - drug effects
Lung - enzymology
Lung - pathology
Male
Protease Inhibitors - administration & dosage
Protease Inhibitors - therapeutic use
Rats
Rats, Wistar
Respiratory Distress Syndrome, Adult - enzymology
Respiratory Distress Syndrome, Adult - etiology
Respiratory Distress Syndrome, Adult - prevention & control
Toxemia - complications
Toxemia - drug therapy
Toxemia - enzymology
ISSN:2522-9028
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Summary:The results of a combined study of the proteolysis on a model of post-ischemic toxemia in rats showed a decrease in antiproteinase potential and an activation of proteolysis. The activation of proteolysis and inhibition of antiproteinases was observed not only in the blood, but also in the bronchoalveolar secretion. Those changes were accompanied with the changes in the morphological structure of the lungs. The data obtained have shown a high effectiveness of proteinase inhibitor (contrical) and an antioxidant of flavonoid group (corvetine). Those drugs decreased the morphological changes in the lungs and prevented the development of imbalance in proteinase-inhibitor system. The prophylactic effect was more considerable when both drugs were used in a combined way.
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ISSN:2522-9028