Experimental approach to the prophylaxis and treatment of acute lung injury syndrome with proteinase inhibitors and corvitin
The results of a combined study of the proteolysis on a model of post-ischemic toxemia in rats showed a decrease in antiproteinase potential and an activation of proteolysis. The activation of proteolysis and inhibition of antiproteinases was observed not only in the blood, but also in the bronchoal...
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| Veröffentlicht in: | Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) Jg. 49; H. 4; S. 63 |
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| Format: | Journal Article |
| Sprache: | Ukrainisch |
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Ukraine
2003
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| ISSN: | 2522-9028 |
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| Abstract | The results of a combined study of the proteolysis on a model of post-ischemic toxemia in rats showed a decrease in antiproteinase potential and an activation of proteolysis. The activation of proteolysis and inhibition of antiproteinases was observed not only in the blood, but also in the bronchoalveolar secretion. Those changes were accompanied with the changes in the morphological structure of the lungs. The data obtained have shown a high effectiveness of proteinase inhibitor (contrical) and an antioxidant of flavonoid group (corvetine). Those drugs decreased the morphological changes in the lungs and prevented the development of imbalance in proteinase-inhibitor system. The prophylactic effect was more considerable when both drugs were used in a combined way. |
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| AbstractList | The results of a combined study of the proteolysis on a model of post-ischemic toxemia in rats showed a decrease in antiproteinase potential and an activation of proteolysis. The activation of proteolysis and inhibition of antiproteinases was observed not only in the blood, but also in the bronchoalveolar secretion. Those changes were accompanied with the changes in the morphological structure of the lungs. The data obtained have shown a high effectiveness of proteinase inhibitor (contrical) and an antioxidant of flavonoid group (corvetine). Those drugs decreased the morphological changes in the lungs and prevented the development of imbalance in proteinase-inhibitor system. The prophylactic effect was more considerable when both drugs were used in a combined way.The results of a combined study of the proteolysis on a model of post-ischemic toxemia in rats showed a decrease in antiproteinase potential and an activation of proteolysis. The activation of proteolysis and inhibition of antiproteinases was observed not only in the blood, but also in the bronchoalveolar secretion. Those changes were accompanied with the changes in the morphological structure of the lungs. The data obtained have shown a high effectiveness of proteinase inhibitor (contrical) and an antioxidant of flavonoid group (corvetine). Those drugs decreased the morphological changes in the lungs and prevented the development of imbalance in proteinase-inhibitor system. The prophylactic effect was more considerable when both drugs were used in a combined way. The results of a combined study of the proteolysis on a model of post-ischemic toxemia in rats showed a decrease in antiproteinase potential and an activation of proteolysis. The activation of proteolysis and inhibition of antiproteinases was observed not only in the blood, but also in the bronchoalveolar secretion. Those changes were accompanied with the changes in the morphological structure of the lungs. The data obtained have shown a high effectiveness of proteinase inhibitor (contrical) and an antioxidant of flavonoid group (corvetine). Those drugs decreased the morphological changes in the lungs and prevented the development of imbalance in proteinase-inhibitor system. The prophylactic effect was more considerable when both drugs were used in a combined way. |
| Author | Horokhova, N Iu Semenets', P F Moĭbenko, O O Kubyshkin, A V Kharchenko, V Z |
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| SubjectTerms | Animals Aprotinin - therapeutic use Bronchoalveolar Lavage Fluid - cytology Disease Models, Animal Drug Therapy, Combination Endopeptidases - blood Endopeptidases - metabolism Flavonoids - administration & dosage Flavonoids - therapeutic use Lung - drug effects Lung - enzymology Lung - pathology Male Protease Inhibitors - administration & dosage Protease Inhibitors - therapeutic use Rats Rats, Wistar Respiratory Distress Syndrome, Adult - enzymology Respiratory Distress Syndrome, Adult - etiology Respiratory Distress Syndrome, Adult - prevention & control Toxemia - complications Toxemia - drug therapy Toxemia - enzymology |
| Title | Experimental approach to the prophylaxis and treatment of acute lung injury syndrome with proteinase inhibitors and corvitin |
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