Human tripartite motif 5alpha domains responsible for retrovirus restriction activity and specificity

The tripartite motif 5alpha protein (TRIM5alpha) is one of several factors expressed by mammalian cells that inhibit retrovirus replication. Human TRIM5alpha (huTRIM5alpha) inhibits infection by N-tropic murine leukemia virus (N-MLV) but is inactive against human immunodeficiency virus type 1 (HIV-1...

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Bibliographic Details

Published in:	Journal of virology Vol. 79; no. 14; p. 8969
Main Authors:	Perez-Caballero, David, Hatziioannou, Theodora, Yang, Annie, Cowan, Simone, Bieniasz, Paul D
Format:	Journal Article
Language:	English
Published:	United States 01.07.2005
Subjects:	Amino Acid Sequence Antiviral Agents - physiology Carrier Proteins - chemistry Carrier Proteins - physiology HeLa Cells HIV-1 - physiology Humans Leukemia Virus, Murine - physiology Molecular Sequence Data Retroviridae Infections - prevention & control Structure-Activity Relationship
ISSN:	0022-538X
Online Access:	Get more information
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