Effect of kontrikal on the activity of proteolytic enzymes and their inhibitors in blood, state of the bronchoalveolar secretion and the nature of the lung damage in dysenteric intoxication

The development of dysenteric intoxication in rabbits led to an abrupt increase in the blood activity of proteolytic enzymes. This increase was accompanied by the reduced content of alpha 1-antitrypsin, and that of rapid and slow kallikrein inhibitor. Meanwhile there occurred a remarkable decrease i...

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Vydáno v:Farmakologiia i toksikologiia Ročník 44; číslo 5; s. 589
Hlavní autoři: Protsenko, V A, Opryshko, V V, Nesterov, E N, Bogadel'nikov, I V, Kharchenko, V Z
Médium: Journal Article
Jazyk:ruština
Vydáno: Russia (Federation) 01.09.1981
Témata:
Animals
Aprotinin - therapeutic use
Bronchi - secretion
Dysentery, Bacillary - complications
Dysentery, Bacillary - drug therapy
Lung Diseases - drug therapy
Lung Diseases - etiology
Peptide Hydrolases - blood
Protease Inhibitors - blood
Pulmonary Alveoli - secretion
Rabbits
ISSN:0014-8318
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Shrnutí:The development of dysenteric intoxication in rabbits led to an abrupt increase in the blood activity of proteolytic enzymes. This increase was accompanied by the reduced content of alpha 1-antitrypsin, and that of rapid and slow kallikrein inhibitor. Meanwhile there occurred a remarkable decrease in blood serum ability to bind chymotrypsin and kallikrein, and diminution of alpha 2-macroglobulin level. Trypsin, binding by blood serum did not undergo any substantial changes. In these conditions, the permeability of pulmonary vessels drastically rose and surface activity of the washing off dropped. The pathomorphological alterations in the lungs corresponded with the appearance of the "shock lung". Contrykal normalized the blood content of proteolytic enzymes and inhibitors, as well as that of the bronchoalveolar washing off, averted the development of gross pathomorphological alterations, exerting no appreciable effect on the surface activity of the bronchoalveolar washing off.
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ISSN:0014-8318