Effect of kontrikal on the dynamics of proteolytic system indices in postischemic toxemia

It was shown in Wistar male rats that the development of tourniquet shock was followed by an increase of proteolytic activity in the blood by 3 times, activity of aspartate aminotransferase (AST) by 3 times, that of alanine aminotransferase (ALT) by 6 times, contents of urea and residual nitrogen by...

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Bibliographic Details
Published in:	Farmakologiia i toksikologiia Vol. 50; no. 1; p. 64
Main Authors:	Protsenko, V A, Kharchenko, V Z, Kolesnikov, Iu N, Spitsyn, I F, Egorychev, V E
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01.01.1987
Subjects:	Animals Aprotinin - therapeutic use Coronary Disease - complications Coronary Disease - drug therapy Coronary Disease - enzymology Drug Evaluation, Preclinical Male Peptide Hydrolases - blood Rats Rats, Inbred Strains Time Factors Tourniquets - adverse effects Toxemia - drug therapy Toxemia - enzymology Toxemia - etiology
ISSN:	0014-8318
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Summary:	It was shown in Wistar male rats that the development of tourniquet shock was followed by an increase of proteolytic activity in the blood by 3 times, activity of aspartate aminotransferase (AST) by 3 times, that of alanine aminotransferase (ALT) by 6 times, contents of urea and residual nitrogen by 2.5-3 times; level of alpha 1-protease inhibitor (alpha 1-PI) decreased by 4 times and that of alpha 2-macroglobulin (alpha 2MG) by 2.5 times. At administration of contrykal (10,000 U/kg) proteolytic activity increased only by 32.5%, content of alpha 1-PI decreased only by 10-20% and level of alpha 2-MG did not differ from that in healthy animals. Activity of AST and ALT remained high, and contents of urea and residual nitrogen were near-normal.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23
ISSN:	0014-8318