Effect of kontrikal on the dynamics of proteolytic system indices in postischemic toxemia

It was shown in Wistar male rats that the development of tourniquet shock was followed by an increase of proteolytic activity in the blood by 3 times, activity of aspartate aminotransferase (AST) by 3 times, that of alanine aminotransferase (ALT) by 6 times, contents of urea and residual nitrogen by...

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Vydáno v:Farmakologiia i toksikologiia Ročník 50; číslo 1; s. 64
Hlavní autoři: Protsenko, V A, Kharchenko, V Z, Kolesnikov, Iu N, Spitsyn, I F, Egorychev, V E
Médium: Journal Article
Jazyk:ruština
Vydáno: Russia (Federation) 01.01.1987
Témata:
Animals
Aprotinin - therapeutic use
Coronary Disease - complications
Coronary Disease - drug therapy
Coronary Disease - enzymology
Drug Evaluation, Preclinical
Male
Peptide Hydrolases - blood
Rats
Rats, Inbred Strains
Time Factors
Tourniquets - adverse effects
Toxemia - drug therapy
Toxemia - enzymology
Toxemia - etiology
ISSN:0014-8318
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Shrnutí:It was shown in Wistar male rats that the development of tourniquet shock was followed by an increase of proteolytic activity in the blood by 3 times, activity of aspartate aminotransferase (AST) by 3 times, that of alanine aminotransferase (ALT) by 6 times, contents of urea and residual nitrogen by 2.5-3 times; level of alpha 1-protease inhibitor (alpha 1-PI) decreased by 4 times and that of alpha 2-macroglobulin (alpha 2MG) by 2.5 times. At administration of contrykal (10,000 U/kg) proteolytic activity increased only by 32.5%, content of alpha 1-PI decreased only by 10-20% and level of alpha 2-MG did not differ from that in healthy animals. Activity of AST and ALT remained high, and contents of urea and residual nitrogen were near-normal.
Bibliografie:ObjectType-Article-2
SourceType-Scholarly Journals-1
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content type line 23
ISSN:0014-8318