Effect of pancreatic kallikrein and trypsin inhibitors on the course of postischemic toxemia

By studying the ECG findings, dynamic changes of the body temperature, the edemas size in the tourniquet-compressed limbs, vascular permeability of the skin, general condition and survival rate on a model of post-ischemic toxemia in albino rats it was found that the serum containing antibodies to pa...

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Bibliographic Details
Published in:Farmakologiia i toksikologiia Vol. 40; no. 5; p. 609
Main Authors: Kharchenko, V Z, Protsenko, V A
Format: Journal Article
Language:Russian
Published: Russia (Federation) 01.09.1977
Subjects:
Animals
Aprotinin - therapeutic use
Body Temperature
Drug Evaluation, Preclinical
Gangrene - prevention & control
Heart Rate
Hindlimb - blood supply
Immunization, Passive
Ischemia - therapy
Macromolecular Substances
Rabbits
Rats
Toxemia - therapy
ISSN:0014-8318
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Summary:By studying the ECG findings, dynamic changes of the body temperature, the edemas size in the tourniquet-compressed limbs, vascular permeability of the skin, general condition and survival rate on a model of post-ischemic toxemia in albino rats it was found that the serum containing antibodies to pancreatic kallikrein (200 gamma/ml), when introduced parenterally (1 ml per 100 g of the mass), increases the survival time of the animals and prevents the development of gangrene in the ischemic limbs. The curative effect of the antikallikrein serum resembles the action of ingitril, a polyvalent inhibitor (1.5 Un. per 100 g of the mass). The antitryptic serum employed in analogous doses stands by its action close to the normal rabbit's serum.
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ISSN:0014-8318