Effect of pancreatic kallikrein and trypsin inhibitors on the course of postischemic toxemia

By studying the ECG findings, dynamic changes of the body temperature, the edemas size in the tourniquet-compressed limbs, vascular permeability of the skin, general condition and survival rate on a model of post-ischemic toxemia in albino rats it was found that the serum containing antibodies to pa...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Farmakologiia i toksikologiia Jg. 40; H. 5; S. 609
Hauptverfasser: Kharchenko, V Z, Protsenko, V A
Format: Journal Article
Sprache:Russisch
Veröffentlicht: Russia (Federation) 01.09.1977
Schlagworte:
Animals
Aprotinin - therapeutic use
Body Temperature
Drug Evaluation, Preclinical
Gangrene - prevention & control
Heart Rate
Hindlimb - blood supply
Immunization, Passive
Ischemia - therapy
Macromolecular Substances
Rabbits
Rats
Toxemia - therapy
ISSN:0014-8318
Online-Zugang:Weitere Angaben
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:By studying the ECG findings, dynamic changes of the body temperature, the edemas size in the tourniquet-compressed limbs, vascular permeability of the skin, general condition and survival rate on a model of post-ischemic toxemia in albino rats it was found that the serum containing antibodies to pancreatic kallikrein (200 gamma/ml), when introduced parenterally (1 ml per 100 g of the mass), increases the survival time of the animals and prevents the development of gangrene in the ischemic limbs. The curative effect of the antikallikrein serum resembles the action of ingitril, a polyvalent inhibitor (1.5 Un. per 100 g of the mass). The antitryptic serum employed in analogous doses stands by its action close to the normal rabbit's serum.
Bibliographie:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0014-8318