Effect of proteolysis inhibitors on serum proteinase activity and its antitryptic activity in postischemic toxemia

Parenteral administration to animals of the antikallikrein serum containing 200gamma/ml of antibodies to the pancreatic kallikrein (10 ml/kg), ingitryl (1.5 Un/kg) and of tracilol (10 000 Un/kg) exerts in post-ischemic toxemia an inhibiting effect on the protamine-splitting blood serum activity and...

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Bibliographic Details
Published in:Farmakologiia i toksikologiia Vol. 41; no. 6; p. 693
Main Authors: Protsenko, V A, Kharchenko, V Z, Veselov, V F, Spitsyn, I F, Bogadel'nikov, I V
Format: Journal Article
Language:Russian
Published: Russia (Federation) 01.11.1978
Subjects:
Animals
Benzoylarginine Nitroanilide
Immunization, Passive
Ischemia - therapy
Kallikreins - immunology
Male
Peptide Hydrolases - blood
Protamines
Rats
Trypsin - immunology
Trypsin Inhibitors - blood
ISSN:0014-8318
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Summary:Parenteral administration to animals of the antikallikrein serum containing 200gamma/ml of antibodies to the pancreatic kallikrein (10 ml/kg), ingitryl (1.5 Un/kg) and of tracilol (10 000 Un/kg) exerts in post-ischemic toxemia an inhibiting effect on the protamine-splitting blood serum activity and does not affect the benzoylarginine-paranitroanilide rate of splitting. Changes of the blood serum ability to bind trypsin and manifestation of the protamine-splitting activity during the first 9 hours of observation are of an undulating nature and the changes of these characteristics are reciprocal.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:0014-8318