Effect of proteolysis inhibitors on serum proteinase activity and its antitryptic activity in postischemic toxemia

Parenteral administration to animals of the antikallikrein serum containing 200gamma/ml of antibodies to the pancreatic kallikrein (10 ml/kg), ingitryl (1.5 Un/kg) and of tracilol (10 000 Un/kg) exerts in post-ischemic toxemia an inhibiting effect on the protamine-splitting blood serum activity and...

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Vydáno v:Farmakologiia i toksikologiia Ročník 41; číslo 6; s. 693
Hlavní autoři: Protsenko, V A, Kharchenko, V Z, Veselov, V F, Spitsyn, I F, Bogadel'nikov, I V
Médium: Journal Article
Jazyk:ruština
Vydáno: Russia (Federation) 01.11.1978
Témata:
Animals
Benzoylarginine Nitroanilide
Immunization, Passive
Ischemia - therapy
Kallikreins - immunology
Male
Peptide Hydrolases - blood
Protamines
Rats
Trypsin - immunology
Trypsin Inhibitors - blood
ISSN:0014-8318
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Abstract Parenteral administration to animals of the antikallikrein serum containing 200gamma/ml of antibodies to the pancreatic kallikrein (10 ml/kg), ingitryl (1.5 Un/kg) and of tracilol (10 000 Un/kg) exerts in post-ischemic toxemia an inhibiting effect on the protamine-splitting blood serum activity and does not affect the benzoylarginine-paranitroanilide rate of splitting. Changes of the blood serum ability to bind trypsin and manifestation of the protamine-splitting activity during the first 9 hours of observation are of an undulating nature and the changes of these characteristics are reciprocal.
AbstractList Parenteral administration to animals of the antikallikrein serum containing 200gamma/ml of antibodies to the pancreatic kallikrein (10 ml/kg), ingitryl (1.5 Un/kg) and of tracilol (10 000 Un/kg) exerts in post-ischemic toxemia an inhibiting effect on the protamine-splitting blood serum activity and does not affect the benzoylarginine-paranitroanilide rate of splitting. Changes of the blood serum ability to bind trypsin and manifestation of the protamine-splitting activity during the first 9 hours of observation are of an undulating nature and the changes of these characteristics are reciprocal.Parenteral administration to animals of the antikallikrein serum containing 200gamma/ml of antibodies to the pancreatic kallikrein (10 ml/kg), ingitryl (1.5 Un/kg) and of tracilol (10 000 Un/kg) exerts in post-ischemic toxemia an inhibiting effect on the protamine-splitting blood serum activity and does not affect the benzoylarginine-paranitroanilide rate of splitting. Changes of the blood serum ability to bind trypsin and manifestation of the protamine-splitting activity during the first 9 hours of observation are of an undulating nature and the changes of these characteristics are reciprocal.
Parenteral administration to animals of the antikallikrein serum containing 200gamma/ml of antibodies to the pancreatic kallikrein (10 ml/kg), ingitryl (1.5 Un/kg) and of tracilol (10 000 Un/kg) exerts in post-ischemic toxemia an inhibiting effect on the protamine-splitting blood serum activity and does not affect the benzoylarginine-paranitroanilide rate of splitting. Changes of the blood serum ability to bind trypsin and manifestation of the protamine-splitting activity during the first 9 hours of observation are of an undulating nature and the changes of these characteristics are reciprocal.
Author Spitsyn, I F
Bogadel'nikov, I V
Protsenko, V A
Veselov, V F
Kharchenko, V Z
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  givenname: I V
  surname: Bogadel'nikov
  fullname: Bogadel'nikov, I V
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DocumentTitleAlternate Vliianie ingibitorov proteoliza na aktivnost' proteinaz syvorotki krovi i ee antitripticheskuiu aktivnost' pri postishemicheskom toksemii
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SubjectTerms Animals
Benzoylarginine Nitroanilide
Immunization, Passive
Ischemia - therapy
Kallikreins - immunology
Male
Peptide Hydrolases - blood
Protamines
Rats
Trypsin - immunology
Trypsin Inhibitors - blood
Title Effect of proteolysis inhibitors on serum proteinase activity and its antitryptic activity in postischemic toxemia
URI https://www.ncbi.nlm.nih.gov/pubmed/720581
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