Identification of F‐box only protein 7 as a negative regulator of NF‐kappaB signalling

The nuclear factor κB (NF‐κB) signalling pathway controls important cellular events such as cell proliferation, differentiation, apoptosis and immune responses. Pathway activation occurs rapidly upon TNFα stimulation and is highly dependent on ubiquitination events. Using cytoplasmic to nuclear tran...

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Bibliographic Details
Published in:	Journal of cellular and molecular medicine Vol. 16; no. 9; pp. 2140 - 2149
Main Authors:	Kuiken, Hendrik J., Egan, David A., Laman, Heike, Bernards, Rene, Beijersbergen, Roderick L., Dirac, Annette M.
Format:	Journal Article
Language:	English
Published:	England John Wiley & Sons, Inc 01.09.2012 Blackwell Publishing Ltd
Subjects:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism cIAP1 F-Box Proteins - genetics F-Box Proteins - metabolism FBXO7 Gene Expression Regulation HEK293 Cells Humans Immunoblotting Immunoprecipitation Inhibitor of Apoptosis Proteins - genetics Inhibitor of Apoptosis Proteins - metabolism NF-kappa B - genetics NF-kappa B - metabolism NF‐κB signalling Nuclear Pore Complex Proteins - genetics Nuclear Pore Complex Proteins - metabolism Original regulatory ubiquitination RNA interference RNA, Small Interfering - genetics RNA, Small Interfering - metabolism RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Signal Transduction siRNA Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism Ubiquitination
ISSN:	1582-1838, 1582-4934, 1582-4934
Online Access:	Get full text
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