Past, present, and future of circRNAs
Exonic circular RNAs (circRNAs) are covalently closed RNA molecules generated by a process named back‐splicing. circRNAs are highly abundant in eukaryotes, and many of them are evolutionary conserved. In metazoans, circular RNAs are expressed in a tissue‐specific manner, are highly stable, and accum...
Uložené v:
| Vydané v: | The EMBO journal Ročník 38; číslo 16; s. e100836 - n/a |
|---|---|
| Hlavní autori: | , , |
| Médium: | Journal Article |
| Jazyk: | English |
| Vydavateľské údaje: |
London
Nature Publishing Group UK
15.08.2019
Springer Nature B.V John Wiley and Sons Inc |
| Predmet: | |
| ISSN: | 0261-4189, 1460-2075, 1460-2075 |
| On-line prístup: | Získať plný text |
| Tagy: |
Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
|
| Abstract | Exonic circular RNAs (circRNAs) are covalently closed RNA molecules generated by a process named back‐splicing. circRNAs are highly abundant in eukaryotes, and many of them are evolutionary conserved. In metazoans, circular RNAs are expressed in a tissue‐specific manner, are highly stable, and accumulate with age in neural tissues. circRNA biogenesis can regulate the production of the linear RNA counterpart in
cis
as back‐splicing competes with linear splicing. Recent reports also demonstrate functions for some circRNAs in
trans
: Certain circRNAs interact with microRNAs, some are translated, and circRNAs have been shown to regulate immune responses and behavior. Here, we review current knowledge about animal circRNAs and summarize new insights into potential circRNA functions, concepts of their origin, and possible future directions in the field.
Graphical Abstract
This review summarizes the current knowledge on circRNA biogenesis, mechanisms of circRNA expression regulation, their functions and evolution. |
|---|---|
| AbstractList | Exonic circular RNAs (circRNAs) are covalently closed RNA molecules generated by a process named back‐splicing. circRNAs are highly abundant in eukaryotes, and many of them are evolutionary conserved. In metazoans, circular RNAs are expressed in a tissue‐specific manner, are highly stable, and accumulate with age in neural tissues. circRNA biogenesis can regulate the production of the linear RNA counterpart in cis as back‐splicing competes with linear splicing. Recent reports also demonstrate functions for some circRNAs in trans: Certain circRNAs interact with microRNAs, some are translated, and circRNAs have been shown to regulate immune responses and behavior. Here, we review current knowledge about animal circRNAs and summarize new insights into potential circRNA functions, concepts of their origin, and possible future directions in the field. Exonic circular RNAs (circRNAs) are covalently closed RNA molecules generated by a process named back-splicing. circRNAs are highly abundant in eukaryotes, and many of them are evolutionary conserved. In metazoans, circular RNAs are expressed in a tissue-specific manner, are highly stable, and accumulate with age in neural tissues. circRNA biogenesis can regulate the production of the linear RNA counterpart in cis as back-splicing competes with linear splicing. Recent reports also demonstrate functions for some circRNAs in trans: Certain circRNAs interact with microRNAs, some are translated, and circRNAs have been shown to regulate immune responses and behavior. Here, we review current knowledge about animal circRNAs and summarize new insights into potential circRNA functions, concepts of their origin, and possible future directions in the field.Exonic circular RNAs (circRNAs) are covalently closed RNA molecules generated by a process named back-splicing. circRNAs are highly abundant in eukaryotes, and many of them are evolutionary conserved. In metazoans, circular RNAs are expressed in a tissue-specific manner, are highly stable, and accumulate with age in neural tissues. circRNA biogenesis can regulate the production of the linear RNA counterpart in cis as back-splicing competes with linear splicing. Recent reports also demonstrate functions for some circRNAs in trans: Certain circRNAs interact with microRNAs, some are translated, and circRNAs have been shown to regulate immune responses and behavior. Here, we review current knowledge about animal circRNAs and summarize new insights into potential circRNA functions, concepts of their origin, and possible future directions in the field. Exonic circular RNAs (circRNAs) are covalently closed RNA molecules generated by a process named back‐splicing. circRNAs are highly abundant in eukaryotes, and many of them are evolutionary conserved. In metazoans, circular RNAs are expressed in a tissue‐specific manner, are highly stable, and accumulate with age in neural tissues. circRNA biogenesis can regulate the production of the linear RNA counterpart in cis as back‐splicing competes with linear splicing. Recent reports also demonstrate functions for some circRNAs in trans: Certain circRNAs interact with microRNAs, some are translated, and circRNAs have been shown to regulate immune responses and behavior. Here, we review current knowledge about animal circRNAs and summarize new insights into potential circRNA functions, concepts of their origin, and possible future directions in the field. This review summarizes the current knowledge on circRNA biogenesis, mechanisms of circRNA expression regulation, their functions and evolution. Exonic circular RNAs (circRNAs) are covalently closed RNA molecules generated by a process named back‐splicing. circRNAs are highly abundant in eukaryotes, and many of them are evolutionary conserved. In metazoans, circular RNAs are expressed in a tissue‐specific manner, are highly stable, and accumulate with age in neural tissues. circRNA biogenesis can regulate the production of the linear RNA counterpart in cis as back‐splicing competes with linear splicing. Recent reports also demonstrate functions for some circRNAs in trans : Certain circRNAs interact with microRNAs, some are translated, and circRNAs have been shown to regulate immune responses and behavior. Here, we review current knowledge about animal circRNAs and summarize new insights into potential circRNA functions, concepts of their origin, and possible future directions in the field. Graphical Abstract This review summarizes the current knowledge on circRNA biogenesis, mechanisms of circRNA expression regulation, their functions and evolution. |
| Author | Wüst, Stas Patop, Ines Lucia Kadener, Sebastian |
| AuthorAffiliation | 1 Department of Biology Brandeis University Waltham MA USA |
| AuthorAffiliation_xml | – name: 1 Department of Biology Brandeis University Waltham MA USA |
| Author_xml | – sequence: 1 givenname: Ines Lucia surname: Patop fullname: Patop, Ines Lucia organization: Department of Biology, Brandeis University – sequence: 2 givenname: Stas surname: Wüst fullname: Wüst, Stas organization: Department of Biology, Brandeis University – sequence: 3 givenname: Sebastian orcidid: 0000-0003-0080-5987 surname: Kadener fullname: Kadener, Sebastian email: skadener@brandeis.edu organization: Department of Biology, Brandeis University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31343080$$D View this record in MEDLINE/PubMed |
| BookMark | eNp1kd1LwzAUxYMouk3ffZKBCD7YeW_SJimIMIef-IXoc0jbVDu6tiar4n9v3NSp4FMS7u-cnOR0yXJVV4aQTYQBRjSi-2aSjAcUUCKAZHyJdDDkEFAQ0TLpAOUYhCjjNdJ1bgwAkRS4StYYspCBhA7ZudVuutdvrHGm8htdZf28nbbW9Ou8nxY2vbseunWykuvSmY3PtUceTo7vR2fB5c3p-Wh4GTRMxjwwaShzyOIsRxZRrXUsopAmLASTMs0zbRByTnMhUn-5zoTIZCIo02mChmpkPXI4923aZGKy1EeyulSNLSbavqlaF-r3pCqe1GP9ojiPQ4rcG-x-Gtj6uTVuqiaFS01Z6srUrVOUCiYEIBMe3f6DjuvWVv55Mwp4zCTz1NbPRN9Rvn7QAwdz4LUozdv3HEHNGlIfDalFQ-r46uhicfRynMudV1aPxi5S_GfB3gEYg5S_ |
| ContentType | Journal Article |
| Copyright | The Author(s) 2019 2019 The Authors 2019 The Authors. 2019 EMBO |
| Copyright_xml | – notice: The Author(s) 2019 – notice: 2019 The Authors – notice: 2019 The Authors. – notice: 2019 EMBO |
| DBID | CGR CUY CVF ECM EIF NPM 7QG 7QL 7QP 7T5 7TK 7TM 7TO 7U9 8FD C1K FR3 H94 K9. M7N P64 RC3 7X8 5PM |
| DOI | 10.15252/embj.2018100836 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Immunology Abstracts Neurosciences Abstracts Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Virology and AIDS Abstracts Technology Research Database Environmental Sciences and Pollution Management Engineering Research Database AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) Algology Mycology and Protozoology Abstracts (Microbiology C) Biotechnology and BioEngineering Abstracts Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Virology and AIDS Abstracts Oncogenes and Growth Factors Abstracts Technology Research Database Nucleic Acids Abstracts ProQuest Health & Medical Complete (Alumni) Neurosciences Abstracts Biotechnology and BioEngineering Abstracts Environmental Sciences and Pollution Management Genetics Abstracts Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) AIDS and Cancer Research Abstracts Immunology Abstracts Engineering Research Database Calcium & Calcified Tissue Abstracts MEDLINE - Academic |
| DatabaseTitleList | Virology and AIDS Abstracts MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Chemistry Biology |
| DocumentTitleAlternate | Ines Lucia Patop et al |
| EISSN | 1460-2075 |
| EndPage | n/a |
| ExternalDocumentID | PMC6694216 31343080 EMBJ2018100836 10_15252_embj_2018100836 |
| Genre | reviewArticle Journal Article Review Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NIH grantid: R01GM122406; R01AG057700 funderid: 10.13039/100000002 – fundername: Alexander von Humboldt Foundation funderid: 10.13039/100005156 – fundername: NIH funderid: R01GM122406; R01AG057700 – fundername: Alexander von Humboldt Foundation – fundername: NIA NIH HHS grantid: R01 AG057700 – fundername: NIGMS NIH HHS grantid: R01 GM124406 – fundername: NIH HHS grantid: R01AG057700 – fundername: NIH HHS grantid: R01GM122406 – fundername: NIH grantid: R01GM122406; R01AG057700 |
| GroupedDBID | --- -DZ -Q- -~X 0R~ 123 1OC 29G 2WC 33P 36B 39C 53G 5VS 70F 8R4 8R5 A8Z AAESR AAEVG AAHBH AAIHA AAJSJ AAMMB AANLZ AAONW AASGY AASML AAXRX AAYCA AAZKR ABCUV ABLJU ABZEH ACAHQ ACCZN ACGFO ACGFS ACNCT ACPOU ACPRK ACXBN ACXQS ADBBV ADEOM ADKYN ADMGS ADOZA ADXAS ADZMN AEFGJ AEGXH AEIGN AENEX AEUYR AFBPY AFFNX AFGKR AFRAH AFWVQ AFZJQ AGXDD AHMBA AIAGR AIDQK AIDYY AIURR AJAOE ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN AMBMR AMYDB AOIJS AUFTA AZBYB AZFZN AZVAB BAWUL BDRZF BENPR BFHJK BMNLL BMXJE BRXPI BTFSW C6C CS3 DCZOG DIK DPXWK DRFUL DRSTM DU5 E3Z EBD EBLON EBS EJD EMB EMOBN F5P G-S GROUPED_DOAJ GX1 HH5 HK~ HYE KQ8 LATKE LEEKS LITHE LOXES LUTES LYRES MEWTI MRFUL MRSTM MSFUL MSSTM MVM MXFUL MXSTM MY~ NAO O8X O9- OK1 P2P P2W Q2X R.K RHI RNS ROL RPM SV3 TN5 TR2 WBKPD WH7 WIH WIK WIN WOHZO WXSBR YSK ZCA ZZTAW ~KM 24P AAHHS ABJNI ACCFJ AEEZP AEQDE AFPWT AIWBW AJBDE ALIPV RHF WYJ CGR CUY CVF ECM EIF NPM 7QG 7QL 7QP 7T5 7TK 7TM 7TO 7U9 8FD C1K ESTFP FR3 H94 K9. M7N P64 RC3 7X8 5PM |
| ID | FETCH-LOGICAL-p3896-ec48f0d9df1352aaa97542b340ec3a6dae10f62f77c080ad77d8b723acb1e2a13 |
| IEDL.DBID | WIN |
| ISICitedReferencesCount | 987 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000479347300001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0261-4189 1460-2075 |
| IngestDate | Tue Sep 30 15:29:17 EDT 2025 Thu Oct 02 10:40:47 EDT 2025 Mon Oct 06 17:49:25 EDT 2025 Mon Jul 21 06:04:34 EDT 2025 Wed Jan 22 16:39:13 EST 2025 Sat Nov 29 01:24:56 EST 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 16 |
| Keywords | circRNAs splicing RNA processing circular RNAs non‐coding RNAs non-coding RNAs |
| Language | English |
| License | 2019 The Authors. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-p3896-ec48f0d9df1352aaa97542b340ec3a6dae10f62f77c080ad77d8b723acb1e2a13 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 These authors contributed equally to this work |
| ORCID | 0000-0003-0080-5987 |
| PMID | 31343080 |
| PQID | 2273069383 |
| PQPubID | 35985 |
| PageCount | 13 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_6694216 proquest_miscellaneous_2273770137 proquest_journals_2273069383 pubmed_primary_31343080 wiley_primary_10_15252_embj_2018100836_EMBJ2018100836 springer_journals_10_15252_embj_2018100836 |
| PublicationCentury | 2000 |
| PublicationDate | 15 August 2019 |
| PublicationDateYYYYMMDD | 2019-08-15 |
| PublicationDate_xml | – month: 08 year: 2019 text: 15 August 2019 day: 15 |
| PublicationDecade | 2010 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: England – name: New York – name: Hoboken |
| PublicationTitle | The EMBO journal |
| PublicationTitleAbbrev | EMBO J |
| PublicationTitleAlternate | EMBO J |
| PublicationYear | 2019 |
| Publisher | Nature Publishing Group UK Springer Nature B.V John Wiley and Sons Inc |
| Publisher_xml | – name: Nature Publishing Group UK – name: Springer Nature B.V – name: John Wiley and Sons Inc |
| References | 1993; 7 2017; 7 2017; 8 2017; 1 2013; 27 2010; 107 2002; 99 2004; 5 2015; 108 2014; 28 2016a; 26 1992; 11 2017; 357 2007; 35 2018; 48 1998; 395 2003; 12 2013; 19 2018; 7 2018; 6 2018; 174 2018; 9 1976; 73 1993; 73 2017b; 18 2008; 29 2019; 26 2003; 9 2007; 8 2014; 15 1997; 17 2011; 21 1995; 167 2017a; 67 2014; 9 1996; 24 2018; 32 1996; 2 2014; 56 2005; 33 2009; 16 2010; 6 2018; 37 2014; 54 1979; 280 2016; 44 2016; 590 2015; 58 2015; 6 2015; 5 2015; 16 2016b; 15 2015; 18 2019; 74 2017; 27 2017; 66 2017; 68 2017; 67 2015; 10 1998 2016; 98 2011; 30 1996; 93 2015; 208 2011; 39 1999; 8 2014; 159 2018; 25 2001; 20 2018; 24 2016; 11 2018; 19 2011; 147 2016; 6 2016; 7 2015; 25 2018; 110 2015; 29 2017; 14 2006; 88 1991; 64 2017; 13 2015; 21 2019 2018 2013; 495 1992; 20 2008; 40 2012; 7 2017; 544 2019; 177 2012; 40 |
| References_xml | – volume: 18 start-page: 1646 year: 2017b end-page: 1659 article-title: CircHIPK3 sponges miR‐558 to suppress heparanase expression in bladder cancer cells publication-title: EMBO Rep – volume: 495 start-page: 333 year: 2013 end-page: 338 article-title: Circular RNAs are a large class of animal RNAs with regulatory potency publication-title: Nature – volume: 33 start-page: 5904 year: 2005 end-page: 5913 article-title: A genome‐wide survey demonstrates widespread non‐linear mRNA in expressed sequences from multiple species publication-title: Nucleic Acids Res – volume: 44 start-page: 1370 year: 2016 end-page: 1383 article-title: Circular RNAs are long‐lived and display only minimal early alterations in response to a growth factor publication-title: Nucleic Acids Res – volume: 99 start-page: 8185 year: 2002 end-page: 8190 article-title: Regulation of alternative splicing by a transcriptional enhancer through RNA pol II elongation publication-title: Proc Natl Acad Sci USA – volume: 16 start-page: 245 year: 2015 article-title: Spatio‐temporal regulation of circular RNA expression during porcine embryonic brain development publication-title: Genome Biol – volume: 9 start-page: e90859 year: 2014 article-title: Circular RNA is expressed across the eukaryotic tree of life publication-title: PLoS One – volume: 14 start-page: 361 year: 2017 end-page: 369 article-title: Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1 publication-title: RNA Biol – volume: 16 start-page: 113 year: 2015 end-page: 126 article-title: Competition between target sites of regulators shapes post‐transcriptional gene regulation publication-title: Nat Rev Genet – volume: 167 start-page: 245 year: 1995 end-page: 248 article-title: Inverted repeats are necessary for circularization of the mouse testis Sry transcript publication-title: Gene – volume: 107 start-page: 15751 year: 2010 end-page: 15756 article-title: Conserved microRNA targeting in is as widespread in coding regions as in 3′UTRs publication-title: Proc Natl Acad Sci USA – volume: 7 start-page: 5636 year: 2017 article-title: Genome‐wide identification and characterization of circular RNAs by high throughput sequencing in soybean publication-title: Sci Rep – volume: 67 start-page: 228 year: 2017 end-page: 238 article-title: Sensing self and foreign circular RNAs by intron identity publication-title: Mol Cell – volume: 73 start-page: 3852 year: 1976 end-page: 3856 article-title: Viroids are single‐stranded covalently closed circular RNA molecules existing as highly base‐paired rod‐like structures publication-title: Proc Natl Acad Sci USA – volume: 21 start-page: 2076 year: 2015 end-page: 2087 article-title: Transcriptome‐wide investigation of circular RNAs in rice publication-title: RNA – volume: 174 start-page: 350 year: 2018 end-page: 362 article-title: A network of noncoding regulatory RNAs Acts in the mammalian brain publication-title: Cell – volume: 395 start-page: 720 year: 1998 end-page: 724 article-title: Ribonuclease E is a 5′‐end‐dependent endonuclease publication-title: Nature – volume: 9 start-page: 1966 year: 2014 end-page: 1980 article-title: Genome‐wide analysis of circular RNAs reveals their structural and sequence properties and age‐dependent neural accumulation publication-title: Cell Rep – volume: 10 start-page: 170 year: 2015 end-page: 177 article-title: Analysis of intron sequences reveals hallmarks of circular RNA biogenesis in animals publication-title: Cell Rep – volume: 19 start-page: 8 year: 2018 article-title: Global accumulation of circRNAs during aging in publication-title: BMC Genom – volume: 13 start-page: e1007114 year: 2017 article-title: ciRS‐7 exonic sequence is embedded in a long non‐coding RNA locus publication-title: PLoS Genet – volume: 357 start-page: eaam8526 year: 2017 article-title: Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function publication-title: Science – volume: 7 start-page: e30733 year: 2012 article-title: Circular RNAs are the predominant transcript isoform from hundreds of human genes in diverse cell types publication-title: PLoS One – volume: 6 start-page: 2846 year: 2016 end-page: 2858 article-title: Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2 publication-title: Nucleic Acids Res – volume: 27 start-page: 928 year: 2013 end-page: 940 article-title: Structure‐function studies of STAR family Quaking proteins bound to their RNA target sites publication-title: Genes Dev – volume: 8 start-page: 14741 year: 2017 article-title: FUS affects circular RNA expression in murine embryonic stem cell‐derived motor neurons publication-title: Nat Commun – volume: 208 start-page: 88 year: 2015 end-page: 95 article-title: Widespread noncoding circular RNAs in plants publication-title: New Phytol – volume: 177 start-page: 865 year: 2019 end-page: 880 article-title: Structure and degradation of circular RNAs regulate PKR activation in innate immunity publication-title: Cell – volume: 48 start-page: 688 year: 2018 end-page: 701 article-title: A circular RNA protects dormant hematopoietic stem cells from DNA sensor cGAS‐mediated exhaustion publication-title: Immunity – volume: 10 start-page: e0131225 year: 2015 article-title: cir‐ITCH plays an inhibitory role in colorectal cancer by regulating the Wnt/beta‐catenin pathway publication-title: PLoS One – volume: 28 start-page: 2233 year: 2014 end-page: 2247 article-title: Short intronic repeat sequences facilitate circular RNA production publication-title: Genes Dev – volume: 32 start-page: 639 year: 2018 end-page: 644 article-title: A length‐dependent evolutionarily conserved pathway controls nuclear export of circular RNAs publication-title: Genes Dev – volume: 26 start-page: 3444 year: 2019 end-page: 3460 article-title: Expanded expression landscape and prioritization of circular RNAs in mammals publication-title: Cell Rep – volume: 16 start-page: 56 year: 2009 end-page: 62 article-title: The exosome contains domains with specific endoribonuclease, exoribonuclease and cytoplasmic mRNA decay activities publication-title: Nat Struct Mol Biol – volume: 26 start-page: 1277 year: 2016a end-page: 1287 article-title: Diverse alternative back‐splicing and alternative splicing landscape of circular RNAs publication-title: Genome Res – volume: 19 start-page: 141 year: 2013 end-page: 157 article-title: Circular RNAs are abundant, conserved, and associated with ALU repeats publication-title: RNA – volume: 66 start-page: 22 year: 2017 end-page: 37 article-title: Circ‐ZNF609 is a circular RNA that can be translated and functions in myogenesis publication-title: Mol Cell – volume: 9 start-page: 2629 year: 2018 article-title: Engineering circular RNA for potent and stable translation in eukaryotic cells publication-title: Nat Commun – volume: 40 start-page: 1413 year: 2008 end-page: 1415 article-title: Deep surveying of alternative splicing complexity in the human transcriptome by high‐throughput sequencing publication-title: Nat Genet – volume: 88 start-page: 127 year: 2006 end-page: 131 article-title: Reverse transcriptase template switching and false alternative transcripts publication-title: Genomics – volume: 12 start-page: 525 year: 2003 end-page: 532 article-title: A slow RNA polymerase II affects alternative splicing publication-title: Mol Cell – volume: 93 start-page: 6536 year: 1996 end-page: 6541 article-title: Circular RNAs from transcripts of the rat cytochrome P450 2C24 gene: correlation with exon skipping publication-title: Proc Natl Acad Sci USA – volume: 44 start-page: e58 year: 2016 article-title: Comparison of circular RNA prediction tools publication-title: Nucleic Acids Res – volume: 74 start-page: 494 year: 2019 end-page: 507 article-title: Endoribonucleolytic cleavage of m6A‐containing RNAs by RNase P/MRP complex publication-title: Mol Cell – volume: 2 start-page: 603 year: 1996 end-page: 610 article-title: Exon circularization in mammalian nuclear extracts publication-title: RNA – volume: 29 start-page: 178 year: 2008 end-page: 181 article-title: Structural mechanism of RNA recognition by the RIG‐I‐like receptors publication-title: Immunity – volume: 147 start-page: 358 year: 2011 end-page: 369 article-title: A long noncoding RNA controls muscle differentiation by functioning as a competing endogenous RNA publication-title: Cell – volume: 39 start-page: 4464 year: 2011 end-page: 4474 article-title: Structure of p300 bound to MEF2 on DNA reveals a mechanism of enhanceosome assembly publication-title: Nucleic Acids Res – volume: 9 start-page: 319 year: 2003 end-page: 330 article-title: Two reactions of RNA splicing enzymes: joining of exons and circularization of introns publication-title: RNA – volume: 15 start-page: 409 year: 2014 article-title: Expanded identification and characterization of mammalian circular RNAs publication-title: Genome Biol – volume: 7 start-page: 12060 year: 2016 article-title: Comprehensive identification of internal structure and alternative splicing events in circular RNAs publication-title: Nat Commun – volume: 17 start-page: 2985 year: 1997 end-page: 2993 article-title: Exon skipping and circular RNA formation in transcripts of the human cytochrome P‐450 2C18 gene in epidermis and of the rat androgen binding protein gene in testis publication-title: Mol Cell Biol – volume: 8 start-page: 1149 year: 2017 article-title: The circular RNA circBIRC6 participates in the molecular circuitry controlling human pluripotency publication-title: Nat Commun – volume: 74 start-page: 508 year: 2019 end-page: 520 article-title: RNA circularization diminishes immunogenicity and can extend translation duration publication-title: Mol Cell – volume: 56 start-page: 55 year: 2014 end-page: 66 article-title: CircRNA biogenesis competes with Pre‐mRNA splicing publication-title: Mol Cell – volume: 35 start-page: 5474 year: 2007 end-page: 5486 article-title: Muscleblind‐like 1 interacts with RNA hairpins in splicing target and pathogenic RNAs publication-title: Nucleic Acids Res – volume: 27 start-page: 626 year: 2017 end-page: 641 article-title: Extensive translation of circular RNAs driven by N6‐methyladenosine publication-title: Cell Res – volume: 1 start-page: 22 year: 2017 article-title: An overview of the main circRNA databases publication-title: Noncoding RNA Investig – volume: 9 start-page: 1464 year: 2003 end-page: 1475 article-title: The ability to form full‐length intron RNA circles is a general property of nuclear group I introns publication-title: RNA – volume: 8 start-page: 493 year: 1999 end-page: 500 article-title: Circular dystrophin RNAs consisting of exons that were skipped by alternative splicing publication-title: Hum Mol Genet – volume: 98 start-page: 103 year: 2016 end-page: 107 article-title: Characterization of circular RNAs in human, mouse and rat hearts publication-title: J Mol Cell Cardiol – volume: 20 start-page: 5759 year: 2001 end-page: 5768 article-title: Antagonistic effects of T‐Ag and VP16 reveal a role for RNA pol II elongation on alternative splicing publication-title: EMBO J – volume: 10 start-page: 103 year: 2015 end-page: 111 article-title: Exon circularization requires canonical splice signals publication-title: Cell Rep – volume: 6 start-page: 1125 year: 2015 end-page: 1134 article-title: The RNA binding protein quaking regulates formation of circRNAs publication-title: Cell – volume: 544 start-page: 115 year: 2017 end-page: 119 article-title: DHX9 suppresses RNA processing defects originating from the Alu invasion of the human genome publication-title: Nature – volume: 30 start-page: 4414 year: 2011 end-page: 4422 article-title: miRNA‐dependent gene silencing involving Ago2‐mediated cleavage of a circular antisense RNA publication-title: EMBO J – volume: 21 start-page: 172 year: 2015 end-page: 179 article-title: Efficient backsplicing produces translatable circular mRNAs publication-title: RNA – volume: 73 start-page: 1019 year: 1993 end-page: 1030 article-title: Circular transcripts of the testis‐determining gene Sry in adult mouse testis publication-title: Cell – volume: 40 start-page: 3131 year: 2012 end-page: 3142 article-title: Transcriptome‐wide discovery of circular RNAs in Archaea publication-title: Nucleic Acids Res – volume: 66 start-page: 9 year: 2017 end-page: 21 article-title: Translation of CircRNAs publication-title: Mol Cell – volume: 25 start-page: 981 year: 2015 end-page: 984 article-title: Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis publication-title: Cell Res – volume: 147 start-page: 344 year: 2011 end-page: 357 article-title: Coding‐independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs publication-title: Cell – volume: 590 start-page: 3510 year: 2016 end-page: 3516 article-title: Integrative analysis of transcriptomics reveals intuitive splicing mechanism for circular RNA publication-title: FEBS Lett – volume: 110 start-page: 304 year: 2018 end-page: 315 article-title: Novel role of FBXW7 circular RNA in repressing glioma tumorigenesis publication-title: J Natl Cancer Inst – volume: 48 start-page: 121 year: 2018 end-page: 127 article-title: circRNAs in cancer publication-title: Curr Opin Genet Dev – volume: 6 start-page: e1001233 year: 2010 article-title: Expression of linear and novel circular forms of an INK4/ARF‐associated non‐coding RNA correlates with atherosclerosis risk publication-title: PLoS Genet – volume: 6 start-page: 38907 year: 2016 article-title: CircRNA accumulation in the aging mouse brain publication-title: Sci Rep – start-page: 483271 year: 2018 article-title: An knockdown strategy reveals multiple functions for circMbl publication-title: bioRxiv – volume: 280 start-page: 339 year: 1979 end-page: 340 article-title: Electron microscopic evidence for the circular form of RNA in the cytoplasm of eukaryotic cells publication-title: Nature – volume: 11 start-page: 1095 year: 1992 end-page: 1098 article-title: Splicing with inverted order of exons occurs proximal to large introns publication-title: EMBO J – volume: 7 start-page: 155 year: 1993 end-page: 160 article-title: Mis‐splicing yields circular RNA molecules publication-title: FASEB J – volume: 24 start-page: 815 year: 2018 end-page: 827 article-title: Cardiac circRNAs arise mainly from constitutive exons rather than alternatively spliced exons publication-title: RNA – volume: 25 start-page: 244 year: 2018 end-page: 251 article-title: MicroRNA degradation by a conserved target RNA regulates animal behavior publication-title: Nat Struct Mol Biol – volume: 7 start-page: 12429 year: 2016 article-title: Circular non‐coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans publication-title: Nat Commun – volume: 13 start-page: e1005420 year: 2017 article-title: A comprehensive overview and evaluation of circular RNA detection tools publication-title: PLoS Comput Biol – start-page: 355 year: 1998 end-page: 364 – volume: 7 start-page: 1424473 year: 2018 article-title: Selective release of circRNAs in platelet‐derived extracellular vesicles publication-title: J Extracell Vesicles – start-page: 567164 year: 2019 article-title: Nanopore sequencing of full‐length circRNAs in human and mouse brains reveals circRNA‐specific exon usage and intron retention publication-title: bioRxiv – volume: 21 start-page: 1788 year: 2011 end-page: 1799 article-title: Post‐transcriptional exon shuffling events in humans can be evolutionarily conserved and abundant publication-title: Genome Res – volume: 5 start-page: R74 year: 2004 article-title: Variation in alternative splicing across human tissues publication-title: Genome Biol – volume: 159 start-page: 134 year: 2014 end-page: 147 article-title: Complementary sequence‐mediated exon circularization publication-title: Cell – volume: 15 start-page: 611 year: 2016b end-page: 624 article-title: The biogenesis of nascent circular RNAs publication-title: Cell Rep – volume: 54 start-page: 766 year: 2014 end-page: 776 article-title: Assessing the ceRNA hypothesis with quantitative measurements of miRNA and target abundance publication-title: Mol Cell – volume: 14 start-page: 1028 year: 2017 end-page: 1034 article-title: CircRNAs in the brain publication-title: RNA Biol – volume: 6 start-page: 20 year: 2018 article-title: Improved circRNA identification by combining prediction algorithms publication-title: Front Cell Dev Biol – volume: 108 start-page: 20 year: 2015 end-page: 24 article-title: NF90 isoforms, a new family of cellular proteins involved in viral replication? publication-title: Biochimie – volume: 8 start-page: 776 year: 2007 end-page: 789 article-title: Dendritic mRNA: transport, translation and function publication-title: Nat Rev Neurosci – volume: 495 start-page: 384 year: 2013 end-page: 388 article-title: Natural RNA circles function as efficient microRNA sponges publication-title: Nature – volume: 16 start-page: 454 year: 2015 article-title: Strand‐specific RNA sequencing in malaria identifies developmentally regulated long non‐coding RNA and circular RNA publication-title: BMC Genom – volume: 67 start-page: 214 year: 2017a end-page: 227 article-title: Coordinated circRNA biogenesis and function with NF90/NF110 in viral infection publication-title: Mol Cell – volume: 5 start-page: 8057 year: 2015 article-title: Correlation of circular RNA abundance with proliferation – exemplified with colorectal and ovarian cancer, idiopathic lung fibrosis, and normal human tissues publication-title: Sci Rep – volume: 58 start-page: 870 year: 2015 end-page: 885 article-title: Circular RNAs in the mammalian brain are highly abundant, conserved, and dynamically expressed publication-title: Mol Cell – volume: 64 start-page: 607 year: 1991 end-page: 613 article-title: Scrambled exons publication-title: Cell – volume: 20 start-page: 3397 year: 1992 end-page: 3401 article-title: Origin of the Alu family: a family of Alu‐like monomers gave birth to the left and the right arms of the Alu elements publication-title: Nucleic Acids Res – volume: 24 start-page: 1260 year: 1996 end-page: 1266 article-title: generation of a circular exon from a linear pre‐mRNA transcript publication-title: Nucleic Acids Res – volume: 29 start-page: 2168 year: 2015 end-page: 2182 article-title: Combinatorial control of circular RNA expression by intronic repeats, hnRNPs, and SR proteins publication-title: Genes Dev – volume: 37 start-page: 555 year: 2018 end-page: 565 article-title: Circular RNAs in cancer: opportunities and challenges in the field publication-title: Oncogene – volume: 11 start-page: e0148407 year: 2016 article-title: Circular RNAs co‐precipitate with extracellular vesicles: a possible mechanism for circrna clearance publication-title: PLoS One – volume: 68 start-page: 940 year: 2017 end-page: 954 article-title: The output of protein‐coding genes shifts to circular RNAs when the pre‐mRNA processing machinery is limiting publication-title: Mol Cell – volume: 18 start-page: 603 year: 2015 end-page: 610 article-title: Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity publication-title: Nat Neurosci – volume: 7 start-page: 11215 year: 2016 article-title: Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs publication-title: Nat Commun |
| SSID | ssj0005871 |
| Score | 2.7237163 |
| SecondaryResourceType | review_article |
| Snippet | Exonic circular RNAs (circRNAs) are covalently closed RNA molecules generated by a process named back‐splicing. circRNAs are highly abundant in eukaryotes, and... Exonic circular RNAs (circRNAs) are covalently closed RNA molecules generated by a process named back-splicing. circRNAs are highly abundant in eukaryotes, and... |
| SourceID | pubmedcentral proquest pubmed wiley springer |
| SourceType | Open Access Repository Aggregation Database Index Database Publisher |
| StartPage | e100836 |
| SubjectTerms | Animals circRNAs circular RNAs EMBO36 Eukaryotes Evolution, Molecular Evolutionary conservation Humans Immune response Immunity MicroRNAs - genetics miRNA non‐coding RNAs Organ Specificity Review RNA processing RNA Splicing RNA, Circular - genetics Splicing |
| Title | Past, present, and future of circRNAs |
| URI | https://link.springer.com/article/10.15252/embj.2018100836 https://onlinelibrary.wiley.com/doi/abs/10.15252%2Fembj.2018100836 https://www.ncbi.nlm.nih.gov/pubmed/31343080 https://www.proquest.com/docview/2273069383 https://www.proquest.com/docview/2273770137 https://pubmed.ncbi.nlm.nih.gov/PMC6694216 |
| Volume | 38 |
| WOSCitedRecordID | wos000479347300001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVWIB databaseName: Wiley Online Library Free Content customDbUrl: eissn: 1460-2075 dateEnd: 20231231 omitProxy: false ssIdentifier: ssj0005871 issn: 0261-4189 databaseCode: WIN dateStart: 19970101 isFulltext: true titleUrlDefault: https://onlinelibrary.wiley.com providerName: Wiley-Blackwell – providerCode: PRVWIB databaseName: Wiley Online Library Full Collection 2020 customDbUrl: eissn: 1460-2075 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0005871 issn: 0261-4189 databaseCode: DRFUL dateStart: 19970101 isFulltext: true titleUrlDefault: https://onlinelibrary.wiley.com providerName: Wiley-Blackwell |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3JTsMwEB2xCi7sS1iqIMEFEVHHbhwf2SpAUCHE0ltkx44oEmnVFCT-Hk_SppTlgjhadhw744mf7fF7ALvKYnhCjfAS41OPJbF1KcGYZyinIlZ2Bs21AR-ueKMRNpvi812Ygh-i3HBDz8j_1-jgUmUDxR5kDTUv6hljs0Lkp6HIuk0YQRGDx4vGMMojzNdc-TYLI6Hon1RiFYdfKvgJY34PlSzPS0fRbD4d1ef_oyMLMNcHo-5RMXoWYcykSzBdyFO-L8HMyUANbhn2bmTWO3A7xW2lA1em2i34SNx24satbnzbOMpW4L5-dndy7vUlFryORSqBZ2IWJlUtdEIsEpNSClTEVZRVTUxloKUh1STwE86RkVxqznWouE9lrIjxJaGrMJG2U7MOLnLZUaMpcoYxqX3JmR2liaJCUyVqvgNbg88b9f0ki3yLnqqBsMtkB3bKbNs1PLaQqWm_FmU4R2pEB9YKa0SdgoojosS-z7bMAT5ip7IAsmeP5qStp5xFOwgE80ngwP7AosNm4coIjROhaaKhaRyo5ZYsq_-tYHR2fXw5TG788blNmLUJgXvYpLYFE73uq9mGqfit18q6FRjnzbACk6e39furSj7uPwCPJv3X |
| linkProvider | Wiley-Blackwell |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3JTsMwEB2xCi7sS1iDBBfUiDp24_hYKhBLiRBiu0VO7IgikVZdkPh7PEmTqiwXxDGy49h-nvh5bL8BOIwMhydUCyfRLnVYEhuTEow5mnIq4sjMoFlswMcmDwL_-VncTkCjuAuT60OUDje0jOx_jQaODukiZA_Khuq36BUPZ_koUEO9SZhmhm9g_Iany2B0zsPPVl2Zo4URXwz3KrGMky8l_MQyvx-WLHdMx_lsNiGdL_5LU5ZgYchH7Xo-gJZhQqcrMJtHqPxYgblGERBuFY5uZa9fsTv5haWKLVNl55Ikdjux41Y3vgvqvTV4OD-7b1w4wygLTseQFc_RMfOTqhIqIYaMSSkFBsWNKKvqmEpPSU2qiecmnKMouVScKz_iLpVxRLQrCV2HqbSd6k2wUc6OakVRNoxJ5UrOzEBNIioUjUTNtWCn6N9waCq90DUEquoJs1K24KBMNk3DnQuZ6vYgz8M5qiNasJHDEXZyNY6QEvM9UzML-BhQZQYU0B5PSVsvmZC25wnmEs-C4wLSUbVwcYTghAhNOILGgloGZVn8bxnDs5vTq9Hj1h_f24e5i_ubZti8DK63Yd4kCHRpk9oOTPW7A70LM_F7v9Xr7mXD_hOGov9t |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3JbtswEB2kdpvk0sXNotRtVSC5BBZqirQoHhPHRhfXMIw4yE2gRBJxgMiGlwD9-3K0GU7bS9GjRIoiNRzxDZf3AE5ji-EJ1cIz2qceM4l1KcGYpymnIontCJppA94M-HAY3t6K0Q50y7MwOT9ENeGGnpH9r9HB9VyZUrIHaUP1Q3yPm7NCJKihwTOoM9SSqUH9atyfDDY7PcIs7sqmWhgJRbFaiaV8flLGn3Dm79slqzXTbUSbDUn9V_-lMa_hZYFI3Yu8C72BHZ024EWuUfmzAXvdUhLuLZyN5HLVcuf5kaWWK1Pl5qQk7sy4yXSRjIcXywOY9HvX3S9eobPgzS1cCTydsNC0lVCGWDgmpRQoixtT1tYJlYGSmrRN4BvOkZZcKs5VGHOfyiQm2peEHkItnaX6GFwktKNaUSQOY1L5kjPbVU1MhaKx6PgONMvvGxXOsox8C6HagbCxsgOfqmTbNFy7kKmerfM8nCM_ogNHuTmiec7HEVFi32dr5gDfMlSVASm0t1PS6V1GpR0EgvkkcOC8NOmmWhgeoXEiNE20MY0DncyUVfF_yxj1flx-21ye_ONzH2F3dNWPBl-H39_Bvr0vcE6bdJpQWy3W-j08Tx5X0-XiQ9HvfwErLAAl |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Past%2C+present%2C+and+future+of+circRNAs&rft.jtitle=The+EMBO+journal&rft.au=Patop%2C+Ines+Lucia&rft.au=W%C3%BCst%2C+Stas&rft.au=Kadener%2C+Sebastian&rft.date=2019-08-15&rft.eissn=1460-2075&rft.volume=38&rft.issue=16&rft.spage=e100836&rft_id=info:doi/10.15252%2Fembj.2018100836&rft_id=info%3Apmid%2F31343080&rft.externalDocID=31343080 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0261-4189&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0261-4189&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0261-4189&client=summon |