SIRT5 inhibits peroxisomal ACOX1 to prevent oxidative damage and is downregulated in liver cancer

Peroxisomes account for ~35% of total H 2 O 2 generation in mammalian tissues. Peroxisomal ACOX1 (acyl‐CoA oxidase 1) is the first and rate‐limiting enzyme in fatty acid β‐oxidation and a major producer of H 2 O 2 . ACOX1 dysfunction is linked to peroxisomal disorders and hepatocarcinogenesis. Here,...

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Bibliographic Details
Published in:	EMBO reports Vol. 19; no. 5
Main Authors:	Chen, Xiu‐Fei, Tian, Meng‐Xin, Sun, Ren‐Qiang, Zhang, Meng‐Li, Zhou, Li‐Sha, Jin, Lei, Chen, Lei‐Lei, Zhou, Wen‐Jie, Duan, Kun‐Long, Chen, Yu‐Jia, Gao, Chao, Cheng, Zhou‐Li, Wang, Fang, Zhang, Jin‐Ye, Sun, Yi‐Ping, Yu, Hong‐Xiu, Zhao, Yu‐Zheng, Yang, Yi, Liu, Wei‐Ren, Shi, Ying‐Hong, Xiong, Yue, Guan, Kun‐Liang, Ye, Dan
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.05.2018 Springer Nature B.V John Wiley and Sons Inc
Subjects:	ACOX1 Acyl-CoA Oxidase - antagonists & inhibitors Acyl-CoA Oxidase - genetics Acyl-CoA Oxidase - metabolism Animals Carcinoma, Hepatocellular - metabolism Clonal deletion Damage prevention Deoxyribonucleic acid Dimers DNA DNA Damage Down-Regulation EMBO03 EMBO29 EMBO31 Female Gene Knockdown Techniques HEK293 Cells HeLa Cells Hep G2 Cells Hepatocellular carcinoma Homeostasis Humans Hydrogen Peroxide Liver Liver cancer Liver Neoplasms - metabolism Male Metabolism Mice Mice, Knockout Middle Aged Oxidation Oxidation-Reduction Oxidative Stress Peroxisomes Peroxisomes - chemistry Prognosis Reactive oxygen species SIRT5 Sirtuins - genetics Sirtuins - metabolism succinylation SIRT5 liver cancer succinylation ACOX1 oxidative stress
ISSN:	1469-221X, 1469-3178, 1469-3178
Online Access:	Get full text
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