SARS‐CoV‐2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells

The SARS‐CoV‐2 pandemic affecting the human respiratory system severely challenges public health and urgently demands for increasing our understanding of COVID‐19 pathogenesis, especially host factors facilitating virus infection and replication. SARS‐CoV‐2 was reported to enter cells via binding to...

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Veröffentlicht in:	The EMBO journal Jg. 39; H. 10; S. e105114 - n/a
Hauptverfasser:	Lukassen, Soeren, Chua, Robert Lorenz, Trefzer, Timo, Kahn, Nicolas C, Schneider, Marc A, Muley, Thomas, Winter, Hauke, Meister, Michael, Veith, Carmen, Boots, Agnes W, Hennig, Bianca P, Kreuter, Michael, Conrad, Christian, Eils, Roland
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 18.05.2020 Springer Nature B.V John Wiley and Sons Inc
Schlagworte:	ACE2 Adult Aging Angiotensin-Converting Enzyme 2 Binding Bronchi - cytology Bronchi - metabolism Cell differentiation Cells, Cultured Chronic Disease - epidemiology Cofactors Coronavirus Infections - genetics Coronaviruses COVID-19 EMBO09 EMBO10 EMBO23 Epithelial Cells - metabolism epithelial differentiation Epithelium Female FURIN Gene Expression Gene Expression Profiling Gene sequencing Germany Goblet Cells - metabolism Guanosine triphosphatases Human Cell Atlas Humans Infections Lung - cytology Lung - metabolism Lungs Male Middle Aged mRNA Nuclei (cytology) Pandemics Pathogenesis Peptidyl-Dipeptidase A - genetics Pneumonia, Viral - genetics Priming Public health Receptors Reference Standards Resource Respiratory system respiratory tract Sequence Analysis, RNA Serine Endopeptidases - genetics Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Sex Characteristics Single-Cell Analysis Smoking Tissue Banks Viral diseases Viruses Germany FURIN Human Cell Atlas COVID‐19 epithelial differentiation respiratory tract COVID-19
ISSN:	0261-4189, 1460-2075, 1460-2075
Online-Zugang:	Volltext
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