Reward and neurocomputational processes

The neurobiology of eating disorders (EDs) is largely unknown. However, brain imaging studies over the past decade have identified neurotransmitter alterations that could be part of dysfunctional behavior characteristics of EDs. In this chapter we focus on a specific behavioral construct, the brain...

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Bibliographic Details
Published in:Current topics in behavioral neurosciences Vol. 6; p. 95
Main Author: Frank, Guido K W
Format: Journal Article
Language:English
Published: Germany 01.01.2011
Subjects:
Brain - pathology
Computer Simulation
Feeding and Eating Disorders - pathology
Feeding and Eating Disorders - physiopathology
Feeding and Eating Disorders - psychology
Humans
Models, Neurological
Neural Pathways - pathology
Neuroimaging
Reward
ISSN:1866-3370
Online Access:Get more information
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Description
Summary:The neurobiology of eating disorders (EDs) is largely unknown. However, brain imaging studies over the past decade have identified neurotransmitter alterations that could be part of dysfunctional behavior characteristics of EDs. In this chapter we focus on a specific behavioral construct, the brain reward system, and demonstrate a functional brain imaging approach toward identifying dopamine function in anorexia nervosa (AN). We demonstrate how human brain reward activation can be used in a translational approach to test whether computer models, based on basic science research, can predict expected in vivo reward system activation, and how such an approach can identify specific biologic alterations in a psychiatric population.
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ISSN:1866-3370
DOI:10.1007/7854_2010_81