The power of fat and its adipose‐derived stromal cells: emerging concepts for fibrotic scar treatment

Lipofilling or lipografting is a novel and promising treatment method for reduction or prevention of dermal scars after injury. Ample anecdotal evidence from case reports supports the scar‐reducing properties of adipose tissue grafts. However, only a few properly controlled and designed clinical tri...

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Vydáno v:Journal of tissue engineering and regenerative medicine Ročník 11; číslo 11; s. 3220 - 3235
Hlavní autoři: Spiekman, Maroesjka, Dongen, Joris A., Willemsen, Joep C., Hoppe, Delia L., Lei, Berend, Harmsen, Martin C.
Médium: Journal Article
Jazyk:angličtina
Vydáno: England John Wiley & Sons, Inc 01.11.2017
John Wiley and Sons Inc
Témata:
Adipose tissue
Adipose Tissue - metabolism
Adipose Tissue - pathology
adipose‐derived stromal/stem cells
Angiogenesis
Animals
Case reports
Cicatrix - metabolism
Cicatrix - pathology
Cicatrix - therapy
Clinical trials
dermal scar
Extracellular matrix
Fibrosis
Grafts
Humans
Injury prevention
lipofilling
Literature reviews
Medical research
Neuralgia
Pain
Regenerative medicine
Review
Reviews
scar treatment
Scars
Skin
Stem cell transplantation
Stem cells
Stem Cells - metabolism
Stem Cells - pathology
Stromal cells
Stromal Cells - metabolism
Stromal Cells - pathology
stromal vascular fraction
Tissue engineering
Wound Healing
adipose tissue
lipofilling
scar treatment
dermal scar
stromal vascular fraction
adipose-derived stromal/stem cells
ISSN:1932-6254, 1932-7005
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Shrnutí:Lipofilling or lipografting is a novel and promising treatment method for reduction or prevention of dermal scars after injury. Ample anecdotal evidence from case reports supports the scar‐reducing properties of adipose tissue grafts. However, only a few properly controlled and designed clinical trials have been conducted thus far on this topic. Also, the underlying mechanism by which lipofilling improves scar aspect and reduces neuropathic scar pain remains largely undiscovered. Adipose‐derived stromal or stem cells (ADSC) are often described to be responsible for this therapeutic effect of lipofilling. We review the recent literature and discuss anticipated mechanisms that govern anti‐scarring capacity of adipose tissue and its ADSC. Both clinical and animal studies clearly demonstrated that lipofilling and ADSC influence processes associated with wound healing, including extracellular matrix remodelling, angiogenesis and modulation of inflammation in dermal scars. However, randomized clinical trials, providing sufficient level of evidence for lipofilling and/or ADSC as an anti‐scarring treatment, are lacking yet warranted in the near future. © 2017 The Authors Journal of Tissue Engineering and Regenerative Medicine Published by John Wiley & Sons Ltd
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ISSN:1932-6254
1932-7005
DOI:10.1002/term.2213