HIV‐1 Tat C modulates NOX2 and NOX4 expressions through miR‐17 in a human microglial cell line

HIV‐1 invades CNS in the early course of infection, which can lead to the cascade of neuroinflammation. NADPH oxidases (NOXs) are the major producers of reactive oxygen species (ROS), which play important roles during pathogenic insults. The molecular mechanism of ROS generation via microRNA‐mediate...

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Veröffentlicht in:	Journal of neurochemistry Jg. 131; H. 6; S. 803 - 815
Hauptverfasser:	Jadhav, Vaishnavi Sunil, Krause, Karl‐Heinz, Singh, Sunit K.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Blackwell Publishing Ltd 01.12.2014
Schlagworte:	Cell Line Cells, Cultured Cellular biology CNS Cytokines HIV HIV-1 - isolation & purification HIV-1 - metabolism HIV‐1 Tat Human immunodeficiency virus Human immunodeficiency virus 1 Humans Membrane Glycoproteins - metabolism microglia Microglia - metabolism microRNA MicroRNAs - metabolism Mutagenesis, Site-Directed - methods NADPH Oxidase 2 NADPH Oxidase 4 NADPH oxidases NADPH Oxidases - metabolism Neurological disorders Proteins Reactive Oxygen Species - metabolism ROS tat Gene Products, Human Immunodeficiency Virus - isolation & purification tat Gene Products, Human Immunodeficiency Virus - metabolism CNS HIV-1 Tat microRNA NADPH oxidases microglia ROS
ISSN:	0022-3042, 1471-4159, 1471-4159
Online-Zugang:	Volltext
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