Use of Hepatocellular Carcinoma Surveillance in Patients With Cirrhosis: A Systematic Review and Meta‐Analysis
Background and Aims Hepatocellular carcinoma (HCC) surveillance is associated with early tumor detection and improved survival; however, it is often underused in clinical practice. We aimed to characterize surveillance use among patients with cirrhosis and the efficacy of interventions to increase s...
Saved in:
| Published in: | Hepatology (Baltimore, Md.) Vol. 73; no. 2; pp. 713 - 725 |
|---|---|
| Main Authors: | , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
Wolters Kluwer Health, Inc
01.02.2021
|
| Subjects: | |
| ISSN: | 0270-9139, 1527-3350, 1527-3350 |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | Background and Aims
Hepatocellular carcinoma (HCC) surveillance is associated with early tumor detection and improved survival; however, it is often underused in clinical practice. We aimed to characterize surveillance use among patients with cirrhosis and the efficacy of interventions to increase surveillance.
Approach and Results
We performed a systematic literature review using the MEDLINE database from January 2010 through August 2018 to identify cohort studies evaluating HCC surveillance receipt or interventions to increase surveillance in patients with cirrhosis. A pooled estimate for surveillance receipt with 95% confidence intervals was calculated. Correlates of surveillance use were defined from each study and prespecified subgroup analyses. Twenty‐nine studies, with a total of 118,799 patients, met inclusion criteria, with a pooled estimate for surveillance use of 24.0% (95% confidence interval, 18.4‐30.1). In subgroup analyses, the highest surveillance receipt was reported in studies with patients enrolled from subspecialty gastroenterology/hepatology clinics and lowest in studies characterizing surveillance in population‐based cohorts (73.7% versus 8.8%, P < 0.001). Commonly reported correlates of surveillance included higher receipt among patients followed by subspecialists and lower receipt among those with alcohol‐associated or nonalcoholic steatohepatitis (NASH)–related cirrhosis. All eight studies (n = 5,229) evaluating interventions including patient/provider education, inreach (e.g., reminder and recall systems), and population health outreach strategies reported significant increases (range 9.4%‐63.6%) in surveillance receipt.
Conclusions
HCC surveillance remains underused in clinical practice, particularly among patients with alcohol‐associated or NASH‐related cirrhosis and those not followed in subspecialty gastroenterology clinics. Interventions such as provider education, inreach including reminder systems, and population health outreach efforts can significantly increase HCC surveillance. |
|---|---|
| AbstractList | Background and AimsHepatocellular carcinoma (HCC) surveillance is associated with early tumor detection and improved survival; however, it is often underused in clinical practice. We aimed to characterize surveillance use among patients with cirrhosis and the efficacy of interventions to increase surveillance.Approach and ResultsWe performed a systematic literature review using the MEDLINE database from January 2010 through August 2018 to identify cohort studies evaluating HCC surveillance receipt or interventions to increase surveillance in patients with cirrhosis. A pooled estimate for surveillance receipt with 95% confidence intervals was calculated. Correlates of surveillance use were defined from each study and prespecified subgroup analyses. Twenty‐nine studies, with a total of 118,799 patients, met inclusion criteria, with a pooled estimate for surveillance use of 24.0% (95% confidence interval, 18.4‐30.1). In subgroup analyses, the highest surveillance receipt was reported in studies with patients enrolled from subspecialty gastroenterology/hepatology clinics and lowest in studies characterizing surveillance in population‐based cohorts (73.7% versus 8.8%, P < 0.001). Commonly reported correlates of surveillance included higher receipt among patients followed by subspecialists and lower receipt among those with alcohol‐associated or nonalcoholic steatohepatitis (NASH)–related cirrhosis. All eight studies (n = 5,229) evaluating interventions including patient/provider education, inreach (e.g., reminder and recall systems), and population health outreach strategies reported significant increases (range 9.4%‐63.6%) in surveillance receipt.ConclusionsHCC surveillance remains underused in clinical practice, particularly among patients with alcohol‐associated or NASH‐related cirrhosis and those not followed in subspecialty gastroenterology clinics. Interventions such as provider education, inreach including reminder systems, and population health outreach efforts can significantly increase HCC surveillance. Hepatocellular carcinoma (HCC) surveillance is associated with early tumor detection and improved survival; however, it is often underused in clinical practice. We aimed to characterize surveillance use among patients with cirrhosis and the efficacy of interventions to increase surveillance. We performed a systematic literature review using the MEDLINE database from January 2010 through August 2018 to identify cohort studies evaluating HCC surveillance receipt or interventions to increase surveillance in patients with cirrhosis. A pooled estimate for surveillance receipt with 95% confidence intervals was calculated. Correlates of surveillance use were defined from each study and prespecified subgroup analyses. Twenty-nine studies, with a total of 118,799 patients, met inclusion criteria, with a pooled estimate for surveillance use of 24.0% (95% confidence interval, 18.4-30.1). In subgroup analyses, the highest surveillance receipt was reported in studies with patients enrolled from subspecialty gastroenterology/hepatology clinics and lowest in studies characterizing surveillance in population-based cohorts (73.7% versus 8.8%, P < 0.001). Commonly reported correlates of surveillance included higher receipt among patients followed by subspecialists and lower receipt among those with alcohol-associated or nonalcoholic steatohepatitis (NASH)-related cirrhosis. All eight studies (n = 5,229) evaluating interventions including patient/provider education, inreach (e.g., reminder and recall systems), and population health outreach strategies reported significant increases (range 9.4%-63.6%) in surveillance receipt. HCC surveillance remains underused in clinical practice, particularly among patients with alcohol-associated or NASH-related cirrhosis and those not followed in subspecialty gastroenterology clinics. Interventions such as provider education, inreach including reminder systems, and population health outreach efforts can significantly increase HCC surveillance. Hepatocellular carcinoma (HCC) surveillance is associated with early tumor detection and improved survival; however, it is often underused in clinical practice. We aimed to characterize surveillance use among patients with cirrhosis and the efficacy of interventions to increase surveillance.BACKGROUND AND AIMSHepatocellular carcinoma (HCC) surveillance is associated with early tumor detection and improved survival; however, it is often underused in clinical practice. We aimed to characterize surveillance use among patients with cirrhosis and the efficacy of interventions to increase surveillance.We performed a systematic literature review using the MEDLINE database from January 2010 through August 2018 to identify cohort studies evaluating HCC surveillance receipt or interventions to increase surveillance in patients with cirrhosis. A pooled estimate for surveillance receipt with 95% confidence intervals was calculated. Correlates of surveillance use were defined from each study and prespecified subgroup analyses. Twenty-nine studies, with a total of 118,799 patients, met inclusion criteria, with a pooled estimate for surveillance use of 24.0% (95% confidence interval, 18.4-30.1). In subgroup analyses, the highest surveillance receipt was reported in studies with patients enrolled from subspecialty gastroenterology/hepatology clinics and lowest in studies characterizing surveillance in population-based cohorts (73.7% versus 8.8%, P < 0.001). Commonly reported correlates of surveillance included higher receipt among patients followed by subspecialists and lower receipt among those with alcohol-associated or nonalcoholic steatohepatitis (NASH)-related cirrhosis. All eight studies (n = 5,229) evaluating interventions including patient/provider education, inreach (e.g., reminder and recall systems), and population health outreach strategies reported significant increases (range 9.4%-63.6%) in surveillance receipt.APPROACH AND RESULTSWe performed a systematic literature review using the MEDLINE database from January 2010 through August 2018 to identify cohort studies evaluating HCC surveillance receipt or interventions to increase surveillance in patients with cirrhosis. A pooled estimate for surveillance receipt with 95% confidence intervals was calculated. Correlates of surveillance use were defined from each study and prespecified subgroup analyses. Twenty-nine studies, with a total of 118,799 patients, met inclusion criteria, with a pooled estimate for surveillance use of 24.0% (95% confidence interval, 18.4-30.1). In subgroup analyses, the highest surveillance receipt was reported in studies with patients enrolled from subspecialty gastroenterology/hepatology clinics and lowest in studies characterizing surveillance in population-based cohorts (73.7% versus 8.8%, P < 0.001). Commonly reported correlates of surveillance included higher receipt among patients followed by subspecialists and lower receipt among those with alcohol-associated or nonalcoholic steatohepatitis (NASH)-related cirrhosis. All eight studies (n = 5,229) evaluating interventions including patient/provider education, inreach (e.g., reminder and recall systems), and population health outreach strategies reported significant increases (range 9.4%-63.6%) in surveillance receipt.HCC surveillance remains underused in clinical practice, particularly among patients with alcohol-associated or NASH-related cirrhosis and those not followed in subspecialty gastroenterology clinics. Interventions such as provider education, inreach including reminder systems, and population health outreach efforts can significantly increase HCC surveillance.CONCLUSIONSHCC surveillance remains underused in clinical practice, particularly among patients with alcohol-associated or NASH-related cirrhosis and those not followed in subspecialty gastroenterology clinics. Interventions such as provider education, inreach including reminder systems, and population health outreach efforts can significantly increase HCC surveillance. Background and Aims Hepatocellular carcinoma (HCC) surveillance is associated with early tumor detection and improved survival; however, it is often underused in clinical practice. We aimed to characterize surveillance use among patients with cirrhosis and the efficacy of interventions to increase surveillance. Approach and Results We performed a systematic literature review using the MEDLINE database from January 2010 through August 2018 to identify cohort studies evaluating HCC surveillance receipt or interventions to increase surveillance in patients with cirrhosis. A pooled estimate for surveillance receipt with 95% confidence intervals was calculated. Correlates of surveillance use were defined from each study and prespecified subgroup analyses. Twenty‐nine studies, with a total of 118,799 patients, met inclusion criteria, with a pooled estimate for surveillance use of 24.0% (95% confidence interval, 18.4‐30.1). In subgroup analyses, the highest surveillance receipt was reported in studies with patients enrolled from subspecialty gastroenterology/hepatology clinics and lowest in studies characterizing surveillance in population‐based cohorts (73.7% versus 8.8%, P < 0.001). Commonly reported correlates of surveillance included higher receipt among patients followed by subspecialists and lower receipt among those with alcohol‐associated or nonalcoholic steatohepatitis (NASH)–related cirrhosis. All eight studies (n = 5,229) evaluating interventions including patient/provider education, inreach (e.g., reminder and recall systems), and population health outreach strategies reported significant increases (range 9.4%‐63.6%) in surveillance receipt. Conclusions HCC surveillance remains underused in clinical practice, particularly among patients with alcohol‐associated or NASH‐related cirrhosis and those not followed in subspecialty gastroenterology clinics. Interventions such as provider education, inreach including reminder systems, and population health outreach efforts can significantly increase HCC surveillance. |
| Author | Rich, Nicole E. Marrero, Jorge A. Parikh, Neehar D. Wolf, Erin Singal, Amit G. |
| Author_xml | – sequence: 1 givenname: Erin surname: Wolf fullname: Wolf, Erin organization: UT Southwestern Medical Center – sequence: 2 givenname: Nicole E. orcidid: 0000-0003-2740-8818 surname: Rich fullname: Rich, Nicole E. organization: UT Southwestern Medical Center – sequence: 3 givenname: Jorge A. surname: Marrero fullname: Marrero, Jorge A. organization: UT Southwestern Medical Center – sequence: 4 givenname: Neehar D. orcidid: 0000-0002-5874-9933 surname: Parikh fullname: Parikh, Neehar D. organization: University of Michigan – sequence: 5 givenname: Amit G. surname: Singal fullname: Singal, Amit G. email: amit.singal@utsouthwestern.edu organization: UT Southwestern Medical Center |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32383272$$D View this record in MEDLINE/PubMed |
| BookMark | eNpd0U1LwzAYB_Agis6Xg19AAl68dMtLYxtvo0wnTBR1eCxp-pRltGlN2slufgQ_o5_ETqcHTwn8fzwkz_8Q7draAkKnlAwpIWy0gGbIKSdyBw2oYFHAuSC7aEBYRAJJuTxAh94vCSEyZPE-OuCMx5xFbICauQdcF3gKjWprDWXZlcrhRDltbF0p_NS5FZiyVFYDNhY_qNaAbT1-Me0CJ8a5Re2Nv8Jj_LT2LVR9rvEjrAy8YWVzfAet-nz_GFtVrnt4jPYKVXo42Z5HaH49eU6mwez-5jYZz4KG01AGAqRWLKcxj_I455mSBdMUQk0yIbWOdVzIgoooVwUPs0wWeZgJJaJIZ3FORcaP0MXP3MbVrx34Nq2M3_xPWag7n7KQEBFeci57ev6PLuvO9e_dqFhSQWTEenW2VV1WQZ42zlTKrdPfXfZg9APeTAnrv5ySdFNS2peUfpeUTicP3xf-BZhNh10 |
| ContentType | Journal Article |
| Copyright | 2020 by the American Association for the Study of Liver Diseases. 2021 by the American Association for the Study of Liver Diseases. |
| Copyright_xml | – notice: 2020 by the American Association for the Study of Liver Diseases. – notice: 2021 by the American Association for the Study of Liver Diseases. |
| DBID | CGR CUY CVF ECM EIF NPM 7T5 7TM 7TO 7U9 H94 K9. 7X8 |
| DOI | 10.1002/hep.31309 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Immunology Abstracts Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Virology and AIDS Abstracts AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) Immunology Abstracts Virology and AIDS Abstracts Oncogenes and Growth Factors Abstracts Nucleic Acids Abstracts MEDLINE - Academic |
| DatabaseTitleList | AIDS and Cancer Research Abstracts MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1527-3350 |
| EndPage | 725 |
| ExternalDocumentID | 32383272 HEP31309 |
| Genre | article Meta-Analysis Systematic Review Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: National Cancer Institute funderid: U01CA230669; U01CA230694 – fundername: NCI NIH HHS grantid: U01 CA230694 – fundername: NCI NIH HHS grantid: U01 CA230669 |
| GroupedDBID | --- --K .3N .55 .GA .GJ .Y3 05W 0R~ 10A 186 1B1 1CY 1L6 1OB 1OC 1ZS 1~5 24P 31~ 33P 3O- 3SF 3WU 4.4 4G. 4ZD 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52S 52T 52U 52V 52W 52X 53G 5GY 5RE 5VS 7-5 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A01 A03 AAEDT AAESR AAEVG AAHHS AALRI AANHP AAONW AAQFI AAQQT AAQXK AASGY AAXRX AAXUO AAZKR ABCQN ABCUV ABEML ABIJN ABLJU ABMAC ABOCM ABPVW ABWVN ABXGK ACAHQ ACBWZ ACCFJ ACCZN ACGFS ACLDA ACMXC ACPOU ACPRK ACRPL ACSCC ACXBN ACXQS ACYXJ ADBBV ADEOM ADIZJ ADKYN ADMGS ADMUD ADNMO ADOZA ADXAS ADZMN ADZOD AECAP AEEZP AEIMD AENEX AEQDE AEUQT AFBPY AFFNX AFGKR AFPWT AFUWQ AFZJQ AHMBA AIACR AIURR AIWBW AJAOE AJBDE ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN AMBMR AMYDB ASPBG ATUGU AVWKF AZBYB AZFZN AZVAB BAFTC BAWUL BDRZF BHBCM BMXJE BROTX BRXPI BY8 C45 CAG COF CS3 D-6 D-7 D-E D-F DCZOG DIK DPXWK DR2 DRFUL DRMAN DRSTM DU5 E3Z EBS EJD F00 F01 F04 F5P FD8 FDB FEDTE FGOYB FUBAC G-S G.N GNP GODZA H.X HBH HF~ HHY HHZ HVGLF HZ~ IHE IX1 J0M J5H JPC KBYEO KQQ LATKE LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES M41 M65 MJL MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM N04 N05 N4W N9A NF~ NNB NQ- O66 O9- OIG OK1 OVD P2P P2W P2X P2Z P4B P4D PALCI PQQKQ Q.N Q11 QB0 QRW R.K R2- RGB RIG RIWAO RJQFR ROL RPZ RWI RX1 RYL SEW SSZ SUPJJ TEORI UB1 V2E V9Y W2D W8V W99 WBKPD WH7 WHWMO WIB WIH WIJ WIK WIN WJL WOHZO WQJ WRC WUP WVDHM WXI X7M XG1 XV2 ZGI ZXP ZZTAW ~IA ~WT ABJNI ACIJW CGR CUY CVF ECM EIF NPM 7T5 7TM 7TO 7U9 AAMMB ACZKN ADSXY AEFGJ AFNMH AGXDD AHQVU AIDQK AIDYY H94 K9. MEWTI O8X WXSBR 7X8 |
| ID | FETCH-LOGICAL-p3149-5e9ca2d1837d8d3ba9f2c1e4c0b59cc8c8f9f157daf34bb9fd4b5a577cb8d15b3 |
| IEDL.DBID | DRFUL |
| ISICitedReferencesCount | 249 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000590608600001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0270-9139 1527-3350 |
| IngestDate | Fri Sep 05 07:21:12 EDT 2025 Sat Nov 29 14:22:37 EST 2025 Wed Feb 19 02:25:07 EST 2025 Wed Jan 22 16:31:12 EST 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Language | English |
| License | 2020 by the American Association for the Study of Liver Diseases. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-p3149-5e9ca2d1837d8d3ba9f2c1e4c0b59cc8c8f9f157daf34bb9fd4b5a577cb8d15b3 |
| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 content type line 14 ObjectType-Feature-3 ObjectType-Evidence Based Healthcare-1 ObjectType-Article-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3 |
| ORCID | 0000-0003-2740-8818 0000-0002-5874-9933 |
| OpenAccessLink | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.31309 |
| PMID | 32383272 |
| PQID | 2489150972 |
| PQPubID | 996352 |
| PageCount | 13 |
| ParticipantIDs | proquest_miscellaneous_2400546339 proquest_journals_2489150972 pubmed_primary_32383272 wiley_primary_10_1002_hep_31309_HEP31309 |
| PublicationCentury | 2000 |
| PublicationDate | February 2021 2021-02-00 20210201 |
| PublicationDateYYYYMMDD | 2021-02-01 |
| PublicationDate_xml | – month: 02 year: 2021 text: February 2021 |
| PublicationDecade | 2020 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: Hoboken |
| PublicationTitle | Hepatology (Baltimore, Md.) |
| PublicationTitleAlternate | Hepatology |
| PublicationYear | 2021 |
| Publisher | Wolters Kluwer Health, Inc |
| Publisher_xml | – name: Wolters Kluwer Health, Inc |
| References | 2015; 35 2019; 53 2019; 17 2017; 152 2011; 56 2016; 71 2014; 174 2011; 154 2013; 19 2017; 72 2013; 58 2010; 26 2018; 5 2017; 37 2019; 69 2016; 43 2014; 13 2012; 27 2011; 365 2014; 11 2015; 13 2013; 47 2013; 43 2013; 108 2017; 66 2017; 65 2004; 140 2015; 10 2016; 95 2016; 50 2015; 128 2018; 67 2018; 69 2018; 68 2011; 9 2017; 51 2004; 53 2015; 27 2010; 46 2015; 63 2017; 12 2016; 65 2018 2011; 43 2011; 45 2014; 74 2012; 5 2010; 52 2016; 22 33617660 - Hepatology. 2021 Sep;74(3):1715 33617661 - Hepatology. 2021 Sep;74(3):1714-1715 |
| References_xml | – volume: 35 start-page: 1862 year: 2015 end-page: 1871 article-title: Application of hepatocellular carcinoma surveillance in a European setting. What can we learn from clinical practice? publication-title: Liver Int – volume: 45 start-page: 727 year: 2011 end-page: 732 article-title: Patient involvement in healthcare is associated with higher rates of surveillance for hepatocellular carcinoma publication-title: J Clin Gastroenterol – volume: 53 start-page: 744 year: 2004 end-page: 749 article-title: Natural history of compensated viral cirrhosis: a prospective study on the incidence and hierarchy of major complications publication-title: Gut – volume: 27 start-page: 1103 year: 2015 end-page: 1108 article-title: A training program for primary care physicians improves the effectiveness of ultrasound surveillance of hepatocellular carcinoma publication-title: Eur J Gastroenterol Hepatol – volume: 5 year: 2018 article-title: Rate of hepatocellular carcinoma surveillance remains low for a large, real‐life cohort of patients with hepatitis C cirrhosis publication-title: BMJ Open Gastroenterol – volume: 17 start-page: 766 year: 2019 end-page: 773 article-title: Primary care provider practice patterns and barriers to hepatocellular carcinoma surveillance publication-title: Clin Gastroenterol Hepatol – volume: 71 start-page: 361 year: 2016 end-page: 364 article-title: Socioeconomic disparities in access to a hepatocellular carcinoma screening program in Brazil publication-title: Clinics (Sao Paulo) – volume: 58 start-page: 1157 year: 2013 end-page: 1160 article-title: Quality improvement measures lead to higher surveillance rates for hepatocellular carcinoma in patients with cirrhosis publication-title: Dig Dis Sci – volume: 72 start-page: 338.e11 year: 2017 end-page: 338.e17 article-title: Ultrasound surveillance for hepatocellular carcinoma: service evaluation of a radiology‐led recall system in a tertiary‐referral centre for liver diseases in the UK publication-title: Clin Radiol – volume: 65 start-page: 864 year: 2017 end-page: 874 article-title: Identifying barriers to hepatocellular carcinoma surveillance in a national sample of patients with cirrhosis publication-title: Hepatology – volume: 43 start-page: 772 year: 2013 end-page: 777 article-title: Optimisation of hepatocellular carcinoma surveillance in patients with viral hepatitis: a quality improvement study publication-title: Intern Med J – volume: 43 start-page: 621 year: 2016 end-page: 630 article-title: Cirrhosis is under‐recognised in patients subsequently diagnosed with hepatocellular cancer publication-title: Aliment Pharmacol Ther – volume: 53 start-page: 142 year: 2019 end-page: 146 article-title: Inadequate hepatocellular carcinoma screening in patients with nonalcoholic steatohepatitis cirrhosis publication-title: J Clin Gastroenterol – volume: 22 start-page: 3 issue: Suppl. 2 year: 2016 end-page: 11 article-title: Nurse‐led hepatocellular carcinoma surveillance clinic provides an effective method of monitoring patients with cirrhosis publication-title: Int J Nurs Pract – volume: 19 start-page: 3207 year: 2013 end-page: 3216 article-title: Epidemiology, clinical‐treatment patterns and outcome in 256 hepatocellular carcinoma cases publication-title: World J Gastroenterol – volume: 56 start-page: 3316 year: 2011 end-page: 3322 article-title: Hepatocellular carcinoma screening rates vary by etiology of cirrhosis and involvement of gastrointestinal sub‐specialists publication-title: Dig Dis Sci – volume: 152 start-page: 608 year: 2017 end-page: 615 article-title: Mailed outreach program increases ultrasound screening of patients with cirrhosis for hepatocellular carcinoma publication-title: Gastroenterology – volume: 174 start-page: 1235 year: 2014 end-page: 1241 article-title: Comparative effectiveness of a multifaceted intervention to improve adherence to annual colorectal cancer screening in community health centers: a randomized clinical trial publication-title: JAMA Intern Med – volume: 50 start-page: 258 year: 2016 end-page: 265 article-title: Hepatocellular carcinoma surveillance among cirrhotic patients with commercial health insurance publication-title: J Clin Gastroenterol – volume: 65 start-page: 1148 year: 2016 end-page: 1154 article-title: Effectiveness of surveillance for hepatocellular carcinoma in clinical practice: a United States cohort publication-title: J Hepatol – volume: 65 start-page: 875 year: 2017 end-page: 884 article-title: Patient‐reported barriers are associated with lower hepatocellular carcinoma surveillance rates in patients with cirrhosis publication-title: Hepatology – volume: 17 start-page: 976 year: 2019 end-page: 987.e4 article-title: Hepatocellular carcinoma screening is associated with increased survival of patients with cirrhosis publication-title: Clin Gastroenterol Hepatol – volume: 74 start-page: 2913 year: 2014 end-page: 2921 article-title: Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States publication-title: Cancer Res – volume: 47 start-page: 713 year: 2013 end-page: 718 article-title: Surveillance for hepatocellular carcinoma in a Medicaid cirrhotic population publication-title: J Clin Gastroenterol – volume: 13 start-page: 204 year: 2014 end-page: 210 article-title: Factors affecting screening for hepatocellular carcinoma publication-title: Ann Hepatol – volume: 68 start-page: 394 year: 2018 end-page: 424 article-title: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries publication-title: CA Cancer J Clin – volume: 51 start-page: 650 year: 2017 end-page: 655 article-title: Hepatocellular carcinoma surveillance among patients with cirrhosis in a population‐based integrated health care delivery system publication-title: J Clin Gastroenterol – volume: 52 start-page: 132 year: 2010 end-page: 141 article-title: Use of surveillance for hepatocellular carcinoma among patients with cirrhosis in the United States publication-title: Hepatology – volume: 63 start-page: 1156 year: 2015 end-page: 1163 article-title: Surveillance for hepatocellular carcinoma is associated with increased survival: results from a large cohort in the Netherlands publication-title: J Hepatol – volume: 365 start-page: 1118 year: 2011 end-page: 1127 article-title: Hepatocellular carcinoma publication-title: N Engl J Med – volume: 51 start-page: 557 year: 2017 end-page: 563 article-title: Adherence to a semiannual surveillance program for hepatocellular carcinoma in patients with liver cirrhosis publication-title: J Clin Gastroenterol – volume: 26 start-page: 2183 year: 2010 end-page: 2191 article-title: Population‐based risk factors and resource utilization for HCC: US perspective publication-title: Curr Med Res Opin – volume: 37 start-page: 259 year: 2017 end-page: 270 article-title: The evolutionary scenario of hepatocellular carcinoma in Italy: an update publication-title: Liver Int – volume: 11 year: 2014 article-title: Early detection, curative treatment, and survival rates for hepatocellular carcinoma surveillance in patients with cirrhosis: a meta‐analysis publication-title: PLoS Med – volume: 46 start-page: 744 year: 2010 end-page: 751 article-title: Hepatocellular carcinoma surveillance and appropriate treatment options improve survival for patients with liver cirrhosis publication-title: Eur J Cancer – volume: 13 start-page: 799 year: 2015 end-page: 804 article-title: Suboptimal surveillance for and knowledge of hepatocellular carcinoma among primary care providers publication-title: Clin Gastroenterol Hepatol – volume: 10 year: 2015 article-title: Improved survival in patients with viral hepatitis‐induced hepatocellular carcinoma undergoing recommended abdominal ultrasound surveillance in Ontario: a population‐based retrospective cohort study publication-title: PLoS One – volume: 5 start-page: 1124 year: 2012 end-page: 1130 article-title: Failure rates in the hepatocellular carcinoma surveillance process publication-title: Cancer Prev Res (Phila) – volume: 128 start-page: 90.e1 year: 2015 end-page: 90.e7 article-title: Racial, social, and clinical determinants of hepatocellular carcinoma surveillance publication-title: Am J Med – volume: 9 start-page: 617 year: 2011 end-page: 623.e1 article-title: Factors that affect risk for hepatocellular carcinoma and effects of surveillance publication-title: Clin Gastroenterol Hepatol – volume: 154 start-page: 85 year: 2011 end-page: 93 article-title: Utilization of surveillance for hepatocellular carcinoma among hepatitis C virus‐infected veterans in the United States publication-title: Ann Intern Med – volume: 27 start-page: 861 year: 2012 end-page: 867 article-title: Utilization of hepatocellular carcinoma surveillance among American patients: a systematic review publication-title: J Gen Intern Med – volume: 152 start-page: S1191 year: 2017 end-page: S1192 article-title: Implementing a local hepatoma surveillance program in patients with cirrhosis secondary to hepatitis C‐real world experience in a community based practice publication-title: Gastroenterology – volume: 53 start-page: 65 year: 2019 end-page: 70 article-title: Low rates of retention into hepatocellular carcinoma (HCC) surveillance program after initial HCC screening publication-title: J Clin Gastroenterol – volume: 13 start-page: 791 year: 2015 end-page: 798.e1 article-title: Practice patterns and attitudes of primary care providers and barriers to surveillance of hepatocellular carcinoma in patients with cirrhosis publication-title: Clin Gastroenterol Hepatol – volume: 95 year: 2016 article-title: Poor adherence and low persistency rates for hepatocellular carcinoma surveillance in patients with chronic hepatitis B publication-title: Medicine (Baltimore) – volume: 12 year: 2017 article-title: Oral medications enhance adherence to surveillance for hepatocellular carcinoma and survival in chronic hepatitis B patients publication-title: PLoS One – volume: 108 start-page: 425 year: 2013 end-page: 432 article-title: Detection of hepatocellular carcinoma at advanced stages among patients in the HALT‐C trial: where did surveillance fail? publication-title: Am J Gastroenterol – year: 2018 article-title: Medical monitoring among cirrhotic patients in real world practice: a nationwide US study with 43,915 cirrhotics publication-title: Hepatology – volume: 69 start-page: 182 year: 2018 end-page: 236 article-title: EASL clinical practice guidelines: management of hepatocellular carcinoma publication-title: J Hepatol – volume: 13 start-page: 172 year: 2015 end-page: 179 article-title: Improved surveillance for hepatocellular carcinoma with a primary care‐oriented clinical reminder publication-title: Clin Gastroenterol Hepatol – volume: 66 start-page: 201 year: 2017 end-page: 206 article-title: Cancer screening test use ‐ United States, 2015 publication-title: MMWR Morb Mortal Wkly Rep – volume: 140 start-page: 528 year: 2004 end-page: 532 article-title: Predicting adherence to colonoscopy or flexible sigmoidoscopy on the basis of physician appointment‐keeping behavior publication-title: Ann Intern Med – volume: 43 start-page: 875 year: 2011 end-page: 880 article-title: Changing aetiological factors of hepatocellular carcinoma and their potential impact on the effectiveness of surveillance publication-title: Dig Liver Dis – volume: 67 start-page: 358 year: 2018 end-page: 380 article-title: AASLD guidelines for the treatment of hepatocellular carcinoma publication-title: Hepatology – volume: 69 start-page: 121 year: 2019 end-page: 130 article-title: Mailed outreach invitations significantly improve HCC surveillance rates in patients with cirrhosis: a randomized clinical trial publication-title: Hepatology – reference: 33617660 - Hepatology. 2021 Sep;74(3):1715 – reference: 33617661 - Hepatology. 2021 Sep;74(3):1714-1715 |
| SSID | ssj0009428 |
| Score | 2.6901553 |
| SecondaryResourceType | review_article |
| Snippet | Background and Aims
Hepatocellular carcinoma (HCC) surveillance is associated with early tumor detection and improved survival; however, it is often underused... Hepatocellular carcinoma (HCC) surveillance is associated with early tumor detection and improved survival; however, it is often underused in clinical... Background and AimsHepatocellular carcinoma (HCC) surveillance is associated with early tumor detection and improved survival; however, it is often underused... |
| SourceID | proquest pubmed wiley |
| SourceType | Aggregation Database Index Database Publisher |
| StartPage | 713 |
| SubjectTerms | Carcinoma, Hepatocellular - diagnosis Carcinoma, Hepatocellular - pathology Cirrhosis Clinical medicine Early Detection of Cancer - standards Early Detection of Cancer - statistics & numerical data Gastroenterology Guideline Adherence - standards Guideline Adherence - statistics & numerical data Hepatocellular carcinoma Hepatology Humans Literature reviews Liver cancer Liver cirrhosis Liver Cirrhosis - pathology Liver Neoplasms - diagnosis Liver Neoplasms - pathology Mass Screening - standards Mass Screening - statistics & numerical data Meta-analysis Patient Acceptance of Health Care - statistics & numerical data Population studies Practice Patterns, Physicians' - standards Practice Patterns, Physicians' - statistics & numerical data Surveillance |
| Title | Use of Hepatocellular Carcinoma Surveillance in Patients With Cirrhosis: A Systematic Review and Meta‐Analysis |
| URI | https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fhep.31309 https://www.ncbi.nlm.nih.gov/pubmed/32383272 https://www.proquest.com/docview/2489150972 https://www.proquest.com/docview/2400546339 |
| Volume | 73 |
| WOSCitedRecordID | wos000590608600001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVWIB databaseName: Wiley Online Library Full Collection 2020 customDbUrl: eissn: 1527-3350 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0009428 issn: 0270-9139 databaseCode: DRFUL dateStart: 19960101 isFulltext: true titleUrlDefault: https://onlinelibrary.wiley.com providerName: Wiley-Blackwell |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3LbtQwFL1qpwix4V0YKJWRWLCJmvgR27Cqho5m0VYjysDsIr-iyYJklGS65hP4Rr4EO8mkQmKBxC6SbSnyPdc-174-F-BdIlUcW2ojLVQcUWpZpIRJIuepSZqT1OBOTOfrJb--Fuu1XB7Ax_1bmF4fYjxwC57RrdfBwZVuzu5EQzfOB-x-BZaHcIQ9btkEjj59nq8u7zR3aVda1QdecbhglnthoRifjYP_Riz_5KndRjN_9F-_-BgeDvwSnfeAeAIHrnwK96-GG_RnsF01DlU5WvhtqK3CsX3IQ0WzUFKorL4rdLOrb10oReTRgIoSLXvh1QZ9K9oNmhV1vamaovmAztHNqAKN-isGpEqLrlyrfv34uVc7eQ6r-cWX2SIaqi5EW-LDpYg5aRS23tW5FZZoJXNsEkdNrJk0RhiRyzxh3KqcUK1lbqlminFutLAJ0-QYJmVVupeANKXEcSo506H-OtOpo9qEt7Q-8CE6ncLJfvKzwXWaDFMhPUuVHE_h7djsQR-mRJWu2oU-gWqmhMgpvOiNlm17dY6MeHQRHEa_72wzNvQCzTjzVsk6q2SLi2X38erfu76GBzhktXR52ycwaeudewP3zG1bNPUpHPK1OB1w-Bvrx-Bp |
| linkProvider | Wiley-Blackwell |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3LTtwwFL2iUBU20HeHQutKXXQTkfiRxKgbNDCaqjOjUWFadpFf0WRBMkoyrPmEfmO_BDvJBFXqohK7SLalyPdc-758LsDngAvf11R7Mha-R6lmnohV4BlrmoQpCRVuyHR-TqLZLL6-5vMt-Lp5C9PyQ_QBN6cZzXntFNwFpE8eWEOXxnrs9gjmT2CHWhhZfO-c_xgtJg-ku7TprWo9L99lmPmGWcjHJ_3if1mWfxuqzU0zOnjcPz6H_c7CRGctJF7AlslfwrNpl0N_BatFZVCRorG9iOrCBe5dJSoauqZCeXEj0OW6vDWuGZHFA8pyNG-pVyv0K6uXaJiV5bKosuoUnaHLngcatUkGJHKNpqYWf-5-b_hOXsNidHE1HHtd3wVvRazD5DHDlcDaKnukY02k4ClWgaHKl4wrFas45WnAIi1SQqXkqaaSCRZFSsY6YJK8ge28yM07QJJSYiLKIyZdB3YmQ0Olcq9pretDZDiAo83uJ53yVAmmMbd2Ko_wAD71wxb2bktEboq1m-OMzZAQPoC3rdSSVcvPkRCLL4Ld6i-NcPqBlqIZJ1YqSSOVZHwxbz4O_3_qR9gdX00nyeTb7Pt72MOuxqWp4j6C7bpcm2N4qm7rrCo_dHC8BxO143E |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3LTtwwFL2iA0LdlNLnAC2u1EU3EYkfSVyxQQOjqTqMRtBp2UV-RZNFk1GSYd1P6DfyJbWTTBASC6TuItmWIt977XPt63MAPgdc-L6m2pOx8D1KNfNErALPWGgSpiRUuCHT-TmNZrP45obPt-B08xam5YfoD9xcZDTrtQtws9LpyT1r6NLYjN0uwfwZbFMnIjOA7fOr8WJ6T7pLG21Vm3n57oaZb5iFfHzSD34MWT4Eqs1OM977v398CS86hInOWpfYhy2Tv4Ldy-4O_TWsFpVBRYomdiOqC3dw7ypR0ciJCuXFb4Gu1-WtcWJE1h9QlqN5S71aoV9ZvUSjrCyXRZVVX9EZuu55oFF7yYBErtGlqcXdn78bvpM3sBhf_BhNvE53wVsRmzB5zHAlsLbBHulYEyl4ilVgqPIl40rFKk55GrBIi5RQKXmqqWSCRZGSsQ6YJG9hkBe5eQ9IUkpMRHnEpFNgZzI0VCr3mtamPkSGQzjazH7SBU-VYBpzi1N5hIfwqW-2bu-mROSmWLs-DmyGhPAhvGutlqxafo6EWP8i2I3-0hinb2gpmnFirZI0VkkmF_Pm4-DpXY9hd34-TqbfZt8P4Tl2JS5NEfcRDOpybT7Ajrqts6r82HnjP8jr4uw |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Use+of+Hepatocellular+Carcinoma+Surveillance+in+Patients+With+Cirrhosis%3A+A+Systematic+Review+and+Meta%E2%80%90Analysis&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.au=Wolf%2C+Erin&rft.au=Rich%2C+Nicole+E&rft.au=Marrero%2C+Jorge+A&rft.au=Parikh%2C+Neehar+D&rft.date=2021-02-01&rft.pub=Wolters+Kluwer+Health%2C+Inc&rft.issn=0270-9139&rft.eissn=1527-3350&rft.volume=73&rft.issue=2&rft.spage=713&rft.epage=725&rft_id=info:doi/10.1002%2Fhep.31309&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0270-9139&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0270-9139&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0270-9139&client=summon |