The long non‐coding RNA Paupar promotes KAP1‐dependent chromatin changes and regulates olfactory bulb neurogenesis

Many long non‐coding RNAs (lncRNAs) are expressed during central nervous system (CNS) development, yet their in vivo roles and mechanisms of action remain poorly understood. Paupar , a CNS‐expressed lncRNA, controls neuroblastoma cell growth by binding and modulating the activity of transcriptional...

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Veröffentlicht in:	The EMBO journal Jg. 37; H. 10
Hauptverfasser:	Pavlaki, Ioanna, Alammari, Farah, Sun, Bin, Clark, Neil, Sirey, Tamara, Lee, Sheena, Woodcock, Dan J, Ponting, Chris P, Szele, Francis G, Vance, Keith W
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 15.05.2018 Springer Nature B.V John Wiley and Sons Inc
Schlagworte:	Animals Animals, Newborn Cell Cycle Cell Proliferation Cells, Cultured Central nervous system Chromatin Chromatin - genetics Deposition EMBO09 EMBO27 EMBO36 Epigenesis, Genetic Epigenetics Gene expression gene regulation Genes Genomes Genomics KAP1 lncRNA Mice Neural Stem Cells - cytology Neural Stem Cells - metabolism Neuroblastoma Neuroblastoma - genetics Neuroblastoma - metabolism Neuroblastoma - pathology Neurogenesis Non-coding RNA Olfaction Olfactory bulb Olfactory Bulb - cytology Olfactory Bulb - metabolism Pax6 protein PAX6 Transcription Factor - genetics PAX6 Transcription Factor - metabolism Proteins Regulators Regulatory Elements, Transcriptional Regulatory sequences Ribonucleic acid RNA RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism Transcription factors Tripartite Motif-Containing Protein 28 - genetics Tripartite Motif-Containing Protein 28 - metabolism neurogenesis lncRNA KAP1 chromatin gene regulation
ISSN:	0261-4189, 1460-2075, 1460-2075
Online-Zugang:	Volltext
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