Familial multiple sclerosis: case study of three affected siblings

Bencsik K, Rajda C, Seres E, Vörös E, Janáky M, Dibó Gy, Járdánházy T, Vécsei L. Familial multiple sclerosis: case study of three affected siblings. Acta Neurol Scand 2002: 106: 392–395. © Blackwell Munksgaard 2002. We report on three sisters with new‐onset multiple sclerosis (MS). The symptoms of t...

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Published in:Acta neurologica Scandinavica Vol. 106; no. 6; pp. 392 - 395
Main Authors: Bencsik, K., Rajda, C., Seres, E., Vörös, E., Janáky, M., Dibó, Gy, Járdánházy, T., Vécsei, L.
Format: Journal Article
Language:English
Published: Oxford, UK Munksgaard International Publishers 01.12.2002
Blackwell
Subjects:
Adult
Biological and medical sciences
familial
Female
Humans
Magnetic Resonance Imaging
Medical sciences
multiple sclerosis
Multiple Sclerosis - genetics
Multiple Sclerosis - pathology
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Neurology
new‐onset
Risk Factors
Siblings
Human
Nervous system diseases
Multiple sclerosis
Sibling
new-onset
Nuclear magnetic resonance imaging
Inflammatory disease
familial
Familial disease
Central nervous system disease
Medical imagery
Adult
Female
Diagnosis
ISSN:0001-6314, 1600-0404
Online Access:Get full text
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Summary:Bencsik K, Rajda C, Seres E, Vörös E, Janáky M, Dibó Gy, Járdánházy T, Vécsei L. Familial multiple sclerosis: case study of three affected siblings. Acta Neurol Scand 2002: 106: 392–395. © Blackwell Munksgaard 2002. We report on three sisters with new‐onset multiple sclerosis (MS). The symptoms of the eldest sister began in 1993 with lower‐limb weakness and paraesthesia. In 1998, she had limb weakness, nystagmus and ataxia. Magnetic resonance imaging (MRI) of the brain, the cerebrospinal fluid (CSF) examinations, and evoked potentials verified MS. The middle sister exhibited left‐side optic neuritis in 1998. All findings pointed to MS. The third sister had subjective complaints such as paraesthesias and vertigo. MRI and CSF results supported the diagnosis. Both parents and all four grandparents are without neurological signs; the brain MRI examinations on the parents were negative. The prevalence of familial MS in first‐degree relatives is 5–10%, while that in twins is 20–30%. In this case, environmental factors seem to play the crucial role. Although the anamnesis as concerns MS proved negative in the other family members examined here, further genetic examination of the sisters is needed.
Bibliography:ObjectType-Case Study-2
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ISSN:0001-6314
1600-0404
DOI:10.1034/j.1600-0404.2002.01348.x