Validated algorithms for identifying timing of second event of oropharyngeal squamous cell carcinoma using real‐world data

Background Understanding occurrence and timing of second events (recurrence and second primary cancer) is essential for cancer specific survival analysis. However, this information is not readily available in administrative data. Methods Alberta Cancer Registry, physician claims, and other administr...

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Bibliographic Details
Published in:Head & neck Vol. 44; no. 8; pp. 1909 - 1917
Main Authors: Khair, Shahreen, Dort, Joseph C., Quan, May Lynn, Cheung, Winson Y., Sauro, Khara M., Nakoneshny, Steven C., Popowich, Brittany Lynn, Liu, Ping, Wu, Guosong, Xu, Yuan
Format: Journal Article
Language:English
Published: Hoboken, USA John Wiley & Sons, Inc 01.08.2022
Wiley Subscription Services, Inc
Subjects:
algorithm validation
Algorithms
cancer second event
chart review
Head & neck cancer
oropharyngeal squamous cell carcinoma
real‐world data
Squamous cell carcinoma
Throat cancer
algorithm validation
real-world data
cancer second event
chart review
oropharyngeal squamous cell carcinoma
ISSN:1043-3074, 1097-0347, 1097-0347
Online Access:Get full text
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Summary:Background Understanding occurrence and timing of second events (recurrence and second primary cancer) is essential for cancer specific survival analysis. However, this information is not readily available in administrative data. Methods Alberta Cancer Registry, physician claims, and other administrative data were used. Timing of second event was estimated based on our developed algorithm. For validation, the difference, in days between the algorithm estimated and the chart‐reviewed timing of second event. Further, the result of Cox‐regression modeling cancer‐free survival was compared to chart review data. Results Majority (74.3%) of the patients had a difference between the chart‐reviewed and algorithm‐estimated timing of second event falling within the 0–60 days window. Kaplan–Meier curves generated from the estimated data and chart review data were comparable with a 5‐year second‐event‐free survival rate of 75.4% versus 72.5%. Conclusion The algorithm provided an estimated timing of second event similar to that of the chart review.
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ISSN:1043-3074
1097-0347
1097-0347
DOI:10.1002/hed.27109