Intranasal Insulin for Alzheimer’s Disease

Brain insulin signaling contributes to memory function and might be a viable target in the prevention and treatment of memory impairments including Alzheimer’s disease. This short narrative review explores the potential of central nervous system (CNS) insulin administration via the intranasal pathwa...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:CNS drugs Ročník 35; číslo 1; s. 21 - 37
Hlavní autor: Hallschmid, Manfred
Médium: Journal Article
Jazyk:angličtina
Vydáno: Cham Springer International Publishing 01.01.2021
Springer Nature B.V
Témata:
Administration, Intranasal
Alzheimer Disease - drug therapy
Alzheimer Disease - physiopathology
Alzheimer's disease
Animals
Brain - drug effects
Brain - physiopathology
Central nervous system
Clinical trials
Cognition & reasoning
Cognitive ability
Cognitive Dysfunction - drug therapy
Cognitive Dysfunction - physiopathology
Female
Humans
Hypoglycemic Agents - administration & dosage
Hypoglycemic Agents - pharmacology
Hypothalamus
Insulin
Insulin - administration & dosage
Insulin - pharmacology
Insulin Resistance
Male
Medicine
Medicine & Public Health
Memory
Memory - drug effects
Neurodegenerative diseases
Neurology
Neurosciences
Parkinson's disease
Pharmacotherapy
Pituitary
Psychiatry
Psychopharmacology
Review
Review Article
Sex differences
Sex Factors
Sleep
Synaptic plasticity
United States > US
ISSN:1172-7047, 1179-1934, 1179-1934
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:Brain insulin signaling contributes to memory function and might be a viable target in the prevention and treatment of memory impairments including Alzheimer’s disease. This short narrative review explores the potential of central nervous system (CNS) insulin administration via the intranasal pathway to improve memory performance in health and disease, with a focus on the most recent results. Proof-of-concept studies and (pilot) clinical trials in individuals with mild cognitive impairment or Alzheimer’s disease indicate that acute and prolonged intranasal insulin administration enhances memory performance, and suggest that brain insulin resistance is a pathophysiological factor in Alzheimer’s disease with or without concomitant metabolic dysfunction. Intranasally administered insulin is assumed to trigger improvements in synaptic plasticity and regional glucose uptake as well as alleviations of Alzheimer’s disease neuropathology; additional contributions of changes in hypothalamus-pituitary-adrenocortical axis activity and sleep-related mechanisms are discussed. While intranasal insulin delivery has been conclusively demonstrated to be effective and safe, the recent outcomes of large-scale clinical studies underline the need for further investigations, which might also yield new insights into sex differences in the response to intranasal insulin and contribute to the optimization of delivery devices to grasp the full potential of intranasal insulin for Alzheimer’s disease.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
ISSN:1172-7047
1179-1934
1179-1934
DOI:10.1007/s40263-020-00781-x