Preemptive Pharmacogenomic Testing for Precision Medicine: A Comprehensive Analysis of Five Actionable Pharmacogenomic Genes Using Next-Generation DNA Sequencing and a Customized CYP2D6 Genotyping Cascade

Significant barriers, such as lack of professional guidelines, specialized training for interpretation of pharmacogenomics (PGx) data, and insufficient evidence to support clinical utility, prevent preemptive PGx testing from being widely clinically implemented. The current study, as a pilot project...

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Veröffentlicht in:	The Journal of molecular diagnostics : JMD Jg. 18; H. 3; S. 438
Hauptverfasser:	Ji, Yuan, Skierka, Jennifer M, Blommel, Joseph H, Moore, Brenda E, VanCuyk, Douglas L, Bruflat, Jamie K, Peterson, Lisa M, Veldhuizen, Tamra L, Fadra, Numrah, Peterson, Sandra E, Lagerstedt, Susan A, Train, Laura J, Baudhuin, Linnea M, Klee, Eric W, Ferber, Matthew J, Bielinski, Suzette J, Caraballo, Pedro J, Weinshilboum, Richard M, Black, 3rd, John L
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.05.2016
Schlagworte:	Alleles Cytochrome P-450 CYP2C19 - genetics Cytochrome P-450 CYP2C19 - metabolism Cytochrome P-450 CYP2D6 - genetics Cytochrome P-450 CYP2D6 - metabolism Enzyme Activation Gene Duplication Genotype High-Throughput Nucleotide Sequencing Humans Pharmacogenetics - methods Phenotype Precision Medicine - methods
ISSN:	1943-7811, 1943-7811
Online-Zugang:	Weitere Angaben
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