Acid Ceramidase in Melanoma: EXPRESSION, LOCALIZATION, AND EFFECTS OF PHARMACOLOGICAL INHIBITION

Acid ceramidase (AC) is a lysosomal cysteine amidase that controls sphingolipid signaling by lowering the levels of ceramides and concomitantly increasing those of sphingosine and its bioactive metabolite, sphingosine 1-phosphate. In the present study, we evaluated the role of AC-regulated sphingoli...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of biological chemistry Jg. 291; H. 5; S. 2422 - 2434
Hauptverfasser:	Realini, Natalia, Palese, Francesca, Pizzirani, Daniela, Pontis, Silvia, Basit, Abdul, Bach, Anders, Ganesan, Anand, Piomelli, Daniele
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 29.01.2016
Schlagworte:	Acid Ceramidase - metabolism Cell Line, Tumor Cell Proliferation Cell Survival Ceramides - chemistry Down-Regulation Enzyme Inhibitors - chemistry Fibroblasts - metabolism Gene Expression Regulation, Neoplastic HCT116 Cells Hep G2 Cells Humans Inhibitory Concentration 50 Keratinocytes - metabolism Lipids - chemistry Lysophospholipids - metabolism MCF-7 Cells Melanocytes - cytology Melanocytes - metabolism Melanoma - metabolism Microscopy, Confocal Microscopy, Fluorescence Oxidoreductases - metabolism RNA, Small Interfering - metabolism Serine C-Palmitoyltransferase - metabolism Signal Transduction Skin Neoplasms - metabolism Sphingolipids - metabolism Sphingosine - analogs & derivatives Sphingosine - metabolism Uracil - analogs & derivatives Uracil - chemistry melanoma ceramide cancer biology enzyme inhibitor sphingolipid acid ceramidase
ISSN:	1083-351X
Online-Zugang:	Weitere Angaben
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!