GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia

Cannabis use is a heritable trait that has been associated with adverse mental health outcomes. In the largest genome-wide association study (GWAS) for lifetime cannabis use to date (N = 184,765), we identified eight genome-wide significant independent single nucleotide polymorphisms in six regions....

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Vydané v:	Nature neuroscience Ročník 21; číslo 9; s. 1161
Hlavní autori:	Pasman, Joëlle A, Verweij, Karin J H, Gerring, Zachary, Stringer, Sven, Sanchez-Roige, Sandra, Treur, Jorien L, Abdellaoui, Abdel, Nivard, Michel G, Baselmans, Bart M L, Ong, Jue-Sheng, Ip, Hill F, van der Zee, Matthijs D, Bartels, Meike, Day, Felix R, Fontanillas, Pierre, Elson, Sarah L, de Wit, Harriet, Davis, Lea K, MacKillop, James, Derringer, Jaime L, Branje, Susan J T, Hartman, Catharina A, Heath, Andrew C, van Lier, Pol A C, Madden, Pamela A F, Mägi, Reedik, Meeus, Wim, Montgomery, Grant W, Oldehinkel, A J, Pausova, Zdenka, Ramos-Quiroga, Josep A, Paus, Tomas, Ribases, Marta, Kaprio, Jaakko, Boks, Marco P M, Bell, Jordana T, Spector, Tim D, Gelernter, Joel, Boomsma, Dorret I, Martin, Nicholas G, MacGregor, Stuart, Perry, John R B, Palmer, Abraham A, Posthuma, Danielle, Munafò, Marcus R, Gillespie, Nathan A, Derks, Eske M, Vink, Jacqueline M
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 01.09.2018
Predmet:	Adolescent Adult Aged Aged, 80 and over Cell Adhesion Molecules - genetics Databases, Genetic Female Gene Expression Regulation - genetics Genetic Predisposition to Disease Genome-Wide Association Study Genotype Humans Male Marijuana Abuse - genetics Marijuana Abuse - psychology Mendelian Randomization Analysis Mental Health Middle Aged Polymorphism, Single Nucleotide Risk-Taking Schizophrenia - chemically induced Schizophrenia - genetics Young Adult
ISSN:	1546-1726, 1546-1726
On-line prístup:	Zistit podrobnosti o prístupe
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