Long noncoding RNA GHET1 promotes the development of bladder cancer

In spite of the advances in the diagnosis and treatment of bladder cancer, the prognosis of bladder cancer remains relatively poor. As a result, it is vital to identify novel diagnostic and prognostic marker of bladder cancer. A growing volume of literature has implicated the vital role of long nonc...

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Vydané v:International journal of clinical and experimental pathology Ročník 7; číslo 10; s. 7196
Hlavní autori: Li, Lin-Jin, Zhu, Jian-Long, Bao, Wen-Shuo, Chen, Da-Ke, Huang, Wei-Wen, Weng, Zhi-Liang
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States 01.01.2014
Predmet:
Biomarkers, Tumor - genetics
Biomarkers, Tumor - metabolism
Cell Line, Tumor
Cell Movement
Cell Proliferation
Cell Transformation, Neoplastic - genetics
Cell Transformation, Neoplastic - metabolism
Cell Transformation, Neoplastic - pathology
Epithelial-Mesenchymal Transition
Female
Gene Expression Regulation, Neoplastic
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Neoplasm Invasiveness
Prognosis
RNA Interference
RNA, Long Noncoding - genetics
RNA, Long Noncoding - metabolism
Time Factors
Transfection
Tumor Burden
Up-Regulation
Urinary Bladder Neoplasms - genetics
Urinary Bladder Neoplasms - metabolism
Urinary Bladder Neoplasms - mortality
Urinary Bladder Neoplasms - pathology
GHET1
proliferation
Long noncoding RNA
prognosis
bladder cancer
epithelial-mesenchymal-transition
ISSN:1936-2625, 1936-2625
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Shrnutí:In spite of the advances in the diagnosis and treatment of bladder cancer, the prognosis of bladder cancer remains relatively poor. As a result, it is vital to identify novel diagnostic and prognostic marker of bladder cancer. A growing volume of literature has implicated the vital role of long noncoding RNA in the development of cancer. GHET1, a recently identified lncRNA, was initially characterized in gastric cancer. However, its role in bladder cancer remains largely unknown. In this study, we demonstrated that GHET1 was upregulated in bladder cancer tissues compared to adjacent normal tissues and its over-expression correlates with tumor size, advanced tumor and lymph node status, and poor survival. GHET1 knockdown suppressed the proliferation and invasion of bladder cancer cells in vitro. In the meantime, inhibition of GHET1 reversed the epithelial-mesenchymal-transition in bladder cancer cell line. Taken together, our study suggests that the potential use of GHET1 as a prognostic marker and therapeutic target of bladder cancer.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1936-2625
1936-2625