Long noncoding RNA GHET1 promotes the development of bladder cancer
In spite of the advances in the diagnosis and treatment of bladder cancer, the prognosis of bladder cancer remains relatively poor. As a result, it is vital to identify novel diagnostic and prognostic marker of bladder cancer. A growing volume of literature has implicated the vital role of long nonc...
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| Published in: | International journal of clinical and experimental pathology Vol. 7; no. 10; p. 7196 |
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| Main Authors: | , , , , , |
| Format: | Journal Article |
| Language: | English |
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01.01.2014
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| ISSN: | 1936-2625, 1936-2625 |
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| Abstract | In spite of the advances in the diagnosis and treatment of bladder cancer, the prognosis of bladder cancer remains relatively poor. As a result, it is vital to identify novel diagnostic and prognostic marker of bladder cancer. A growing volume of literature has implicated the vital role of long noncoding RNA in the development of cancer. GHET1, a recently identified lncRNA, was initially characterized in gastric cancer. However, its role in bladder cancer remains largely unknown. In this study, we demonstrated that GHET1 was upregulated in bladder cancer tissues compared to adjacent normal tissues and its over-expression correlates with tumor size, advanced tumor and lymph node status, and poor survival. GHET1 knockdown suppressed the proliferation and invasion of bladder cancer cells in vitro. In the meantime, inhibition of GHET1 reversed the epithelial-mesenchymal-transition in bladder cancer cell line. Taken together, our study suggests that the potential use of GHET1 as a prognostic marker and therapeutic target of bladder cancer. |
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| AbstractList | In spite of the advances in the diagnosis and treatment of bladder cancer, the prognosis of bladder cancer remains relatively poor. As a result, it is vital to identify novel diagnostic and prognostic marker of bladder cancer. A growing volume of literature has implicated the vital role of long noncoding RNA in the development of cancer. GHET1, a recently identified lncRNA, was initially characterized in gastric cancer. However, its role in bladder cancer remains largely unknown. In this study, we demonstrated that GHET1 was upregulated in bladder cancer tissues compared to adjacent normal tissues and its over-expression correlates with tumor size, advanced tumor and lymph node status, and poor survival. GHET1 knockdown suppressed the proliferation and invasion of bladder cancer cells in vitro. In the meantime, inhibition of GHET1 reversed the epithelial-mesenchymal-transition in bladder cancer cell line. Taken together, our study suggests that the potential use of GHET1 as a prognostic marker and therapeutic target of bladder cancer. In spite of the advances in the diagnosis and treatment of bladder cancer, the prognosis of bladder cancer remains relatively poor. As a result, it is vital to identify novel diagnostic and prognostic marker of bladder cancer. A growing volume of literature has implicated the vital role of long noncoding RNA in the development of cancer. GHET1, a recently identified lncRNA, was initially characterized in gastric cancer. However, its role in bladder cancer remains largely unknown. In this study, we demonstrated that GHET1 was upregulated in bladder cancer tissues compared to adjacent normal tissues and its over-expression correlates with tumor size, advanced tumor and lymph node status, and poor survival. GHET1 knockdown suppressed the proliferation and invasion of bladder cancer cells in vitro. In the meantime, inhibition of GHET1 reversed the epithelial-mesenchymal-transition in bladder cancer cell line. Taken together, our study suggests that the potential use of GHET1 as a prognostic marker and therapeutic target of bladder cancer.In spite of the advances in the diagnosis and treatment of bladder cancer, the prognosis of bladder cancer remains relatively poor. As a result, it is vital to identify novel diagnostic and prognostic marker of bladder cancer. A growing volume of literature has implicated the vital role of long noncoding RNA in the development of cancer. GHET1, a recently identified lncRNA, was initially characterized in gastric cancer. However, its role in bladder cancer remains largely unknown. In this study, we demonstrated that GHET1 was upregulated in bladder cancer tissues compared to adjacent normal tissues and its over-expression correlates with tumor size, advanced tumor and lymph node status, and poor survival. GHET1 knockdown suppressed the proliferation and invasion of bladder cancer cells in vitro. In the meantime, inhibition of GHET1 reversed the epithelial-mesenchymal-transition in bladder cancer cell line. Taken together, our study suggests that the potential use of GHET1 as a prognostic marker and therapeutic target of bladder cancer. |
| Author | Bao, Wen-Shuo Chen, Da-Ke Huang, Wei-Wen Li, Lin-Jin Zhu, Jian-Long Weng, Zhi-Liang |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25400817$$D View this record in MEDLINE/PubMed |
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| Keywords | GHET1 proliferation Long noncoding RNA prognosis bladder cancer epithelial-mesenchymal-transition |
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| References_xml | – reference: 22820081 - Cancer Biomark. 2011-2012;10(6):259-66 – reference: 25015192 - Tumour Biol. 2014 Oct;35(10):10075-84 – reference: 24655544 - Mol Cancer. 2014;13:68 – reference: 24857549 - Mol Cell. 2014 Jun 5;54(5):777-90 – reference: 23395002 - Mol Cell. 2013 Mar 28;49(6):1083-96 – reference: 24768205 - Cancer Cell. 2014 May 12;25(5):666-81 – reference: 24238219 - Mol Cancer. 2013;12(1):140 – reference: 22722759 - Mol Biosyst. 2012 Sep;8(9):2289-94 – reference: 23847441 - Int J Biol Sci. 2013;9(6):587-97 – reference: 24397586 - FEBS J. 2014 Feb;281(3):802-13 – reference: 24044570 - Biomark Med. 2013 Oct;7(5):779-90 – reference: 24462738 - Biochim Biophys Acta. 2014 May;1842(5):712-25 – reference: 24520312 - PLoS One. 2014;9(2):e84311 – reference: 23239537 - Hepatology. 2013 May;57(5):1882-92 – reference: 24451595 - Eur Urol. 2014 Jul;66(1):59-73 – reference: 24202396 - Nat Med. 2013 Nov;19(11):1438-49 – reference: 22300815 - Trends Biochem Sci. 2012 Apr;37(4):144-51 – reference: 24220339 - Biochem Biophys Res Commun. 2013 Nov 29;441(4):976-81 – reference: 24473064 - Cancer Res. 2014 Mar 15;74(6):1651-60 – reference: 23887298 - Mod Pathol. 2014 Feb;27(2):271-80 – reference: 19878561 - BMC Cancer. 2009;9:385 – reference: 23561968 - Pancreatology. 2013 Mar-Apr;13(2):114-7 – reference: 24202173 - Science. 2013 Nov 8;342(6159):1234850 – reference: 24777035 - Nat Commun. 2014;5:3756 |
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| SubjectTerms | Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Cell Line, Tumor Cell Movement Cell Proliferation Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Cell Transformation, Neoplastic - pathology Epithelial-Mesenchymal Transition Female Gene Expression Regulation, Neoplastic Humans Kaplan-Meier Estimate Male Middle Aged Neoplasm Invasiveness Prognosis RNA Interference RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism Time Factors Transfection Tumor Burden Up-Regulation Urinary Bladder Neoplasms - genetics Urinary Bladder Neoplasms - metabolism Urinary Bladder Neoplasms - mortality Urinary Bladder Neoplasms - pathology |
| Title | Long noncoding RNA GHET1 promotes the development of bladder cancer |
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