The cannabinoid agonist WIN55,212-2 increases intracellular calcium via CB1 receptor coupling to Gq/11 G proteins

Central nervous system responses to cannabis are primarily mediated by CB(1) receptors, which couple preferentially to G(i/o) G proteins. Here, we used calcium photometry to monitor the effect of CB(1) activation on intracellular calcium concentration. Perfusion with 5 microM CB(1) aminoalkylindole...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 102; no. 52; p. 19144
Main Authors:	Lauckner, Jane E, Hille, Bertil, Mackie, Ken
Format:	Journal Article
Language:	English
Published:	United States 27.12.2005
Subjects:	Analgesics - pharmacology Animals Arachidonic Acids - chemistry Benzoxazines Calcium - chemistry Calcium - metabolism Cannabinoids - chemistry Cell Line Cyclohexanols - pharmacology Cytoplasm - metabolism DNA, Complementary - metabolism Dronabinol - analogs & derivatives Dronabinol - pharmacology Endocannabinoids Endoplasmic Reticulum - metabolism Excitatory Amino Acid Antagonists - pharmacology Fluorescent Dyes - pharmacology Fura-2 - analogs & derivatives Fura-2 - pharmacology Glycerides - chemistry GTP-Binding Protein alpha Subunits, Gq-G11 - chemistry GTP-Binding Protein alpha Subunits, Gq-G11 - physiology Hippocampus - metabolism Humans Immunosuppressive Agents - pharmacology Morpholines - pharmacology Naphthalenes - pharmacology Neurons - metabolism Pertussis Toxin - pharmacology Piperidines - pharmacology Protein Binding Protein Conformation Pyrazoles - pharmacology Rats Receptor, Cannabinoid, CB1 - chemistry Receptor, Cannabinoid, CB1 - metabolism Rimonabant Ryanodine - pharmacology Time Factors Type C Phospholipases - metabolism
ISSN:	0027-8424
Online Access:	Get more information
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