Hypoxia-induced p53 modulates both apoptosis and radiosensitivity via AKT

Restoration of hypoxia-induced apoptosis in tumors harboring p53 mutations has been proposed as a potential therapeutic strategy; however, the transcriptional targets that mediate hypoxia-induced p53-dependent apoptosis remain elusive. Here, we demonstrated that hypoxia-induced p53-dependent apoptos...

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Bibliographic Details
Published in:	The Journal of clinical investigation Vol. 125; no. 6; p. 2385
Main Authors:	Leszczynska, Katarzyna B, Foskolou, Iosifina P, Abraham, Aswin G, Anbalagan, Selvakumar, Tellier, Céline, Haider, Syed, Span, Paul N, O'Neill, Eric E, Buffa, Francesca M, Hammond, Ester M
Format:	Journal Article
Language:	English
Published:	United States American Society for Clinical Investigation 01.06.2015
Subjects:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Apoptosis Biomedical research Breast cancer Carrier Proteins - genetics Carrier Proteins - metabolism Cell Hypoxia - genetics Cell Line, Tumor DNA damage Humans Immediate-Early Proteins - genetics Immediate-Early Proteins - metabolism Inositol Polyphosphate 5-Phosphatases Mutation Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Nuclear Proteins - genetics Nuclear Proteins - metabolism Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases Phosphoric Monoester Hydrolases - genetics Phosphoric Monoester Hydrolases - metabolism Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Radiation Tolerance Rodents Studies Sulfatases Sulfotransferases - genetics Sulfotransferases - metabolism Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism
ISSN:	0021-9738, 1558-8238, 1558-8238
Online Access:	Get full text
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