Regio‐selectively reduced streptogramin A analogue, 5,6‐dihydrovirginiamycin M1 exhibits improved potency against MRSA

A newly reduced macrocyclic lactone antibiotic streptogramin A, 5,6‐dihydrovirginiamycin M1 was created by feeding virginiamycin M1 into a culture of recombinant Streptomyces venezuelae. Its chemical structure was spectroscopically elucidated, and this streptogramin A analogue showed twofold higher...

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Bibliographic Details
Published in:	Letters in applied microbiology Vol. 57; no. 5; pp. 393 - 398
Main Authors:	Hoang, N.H., Huong, N.L., Shrestha, A., Sohng, J.K., Yoon, Y.J., Park, J.W.
Format:	Journal Article
Language:	English
Published:	Oxford Blackwell 01.11.2013 Oxford University Press
Subjects:	Acetyltransferase Anti-Bacterial Agents - pharmacology Antimicrobial agents Biological and medical sciences Biosynthesis Biotransformation enhanced anti‐MRSA activity Fundamental and applied biological sciences. Psychology Methicillin-Resistant Staphylococcus aureus - drug effects microbial biocatalyst Microbiology reduced macrocyclic lactone Staphylococcus aureus Streptogramin A - analogs & derivatives Streptogramin A - biosynthesis Streptogramin A - chemistry Streptogramin A - pharmacology streptogramin A antibiotic Streptomyces venezuelae Virginiamycin - metabolism Streptomycetaceae reduced macrocyclic lactone Applied microbiology Streptomyces venezuelae Lactone Biocatalyst Macrocycle Actinomycetales Antibiotic streptogramin A antibiotic microbial biocatalyst Analog Bacteria Actinomycetes Microorganism enhanced anti-MRSA activity
ISSN:	0266-8254, 1472-765X, 1472-765X
Online Access:	Get full text
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