Ceftriaxone improves impairments in synaptic plasticity and cognitive behavior in APP/PS1 mouse model of Alzheimer's disease by inhibiting extrasynaptic NMDAR‐STEP61 signaling

Abnormal activation of the extrasynaptic N‐methyl‐d‐aspartate receptor (NMDAR) contributes to the pathogenesis of Alzheimer's disease (AD). Ceftriaxone (Cef) can improve cognitive impairment by upregulating glutamate transporter‐1 and promoting the glutamate–glutamine cycle in an AD mouse model...

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Bibliographic Details
Published in:	Journal of neurochemistry Vol. 166; no. 2; pp. 215 - 232
Main Authors:	He, Ruo‐Bing, Li, Li, Liu, Li‐Zhe, Ma, Ya‐Jun, Fan, Shu‐Juan, Liu, Li‐Rong, Li, Wen‐Bin, Xian, Xiao‐Hui
Format:	Journal Article
Language:	English
Published:	New York Blackwell Publishing Ltd 01.07.2023
Subjects:	Alzheimer's disease Antibiotics APP/PS1 AD mice Behavioral plasticity Calpain Ceftriaxone Centrifugation Cognition & reasoning Cognitive ability Down-regulation Extrasynaptic NMDAR Glutamate receptors Glutamic acid transporter Glutamine Hippocampus Impairment Long-term potentiation MAP kinase N-Methyl-D-aspartic acid receptors Neostriatum Neurodegenerative diseases Pathogenesis Plasticity Presenilin 1 Protein-tyrosine-phosphatase striatal enriched tyrosine phosphatase 61 Synaptic plasticity Tyrosine Viruses
ISSN:	0022-3042, 1471-4159, 1471-4159
Online Access:	Get full text
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