Ceftriaxone improves impairments in synaptic plasticity and cognitive behavior in APP/PS1 mouse model of Alzheimer's disease by inhibiting extrasynaptic NMDAR‐STEP61 signaling

Abnormal activation of the extrasynaptic N‐methyl‐d‐aspartate receptor (NMDAR) contributes to the pathogenesis of Alzheimer's disease (AD). Ceftriaxone (Cef) can improve cognitive impairment by upregulating glutamate transporter‐1 and promoting the glutamate–glutamine cycle in an AD mouse model...

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Vydané v:	Journal of neurochemistry Ročník 166; číslo 2; s. 215 - 232
Hlavní autori:	He, Ruo‐Bing, Li, Li, Liu, Li‐Zhe, Ma, Ya‐Jun, Fan, Shu‐Juan, Liu, Li‐Rong, Li, Wen‐Bin, Xian, Xiao‐Hui
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	New York Blackwell Publishing Ltd 01.07.2023
Predmet:	Alzheimer's disease Antibiotics APP/PS1 AD mice Behavioral plasticity Calpain Ceftriaxone Centrifugation Cognition & reasoning Cognitive ability Down-regulation Extrasynaptic NMDAR Glutamate receptors Glutamic acid transporter Glutamine Hippocampus Impairment Long-term potentiation MAP kinase N-Methyl-D-aspartic acid receptors Neostriatum Neurodegenerative diseases Pathogenesis Plasticity Presenilin 1 Protein-tyrosine-phosphatase striatal enriched tyrosine phosphatase 61 Synaptic plasticity Tyrosine Viruses
ISSN:	0022-3042, 1471-4159, 1471-4159
On-line prístup:	Získať plný text
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