Cuproptosis: Cellular and molecular mechanisms underlying copper-induced cell death

Tsvetkov et al. (2022) discovered a new form of cell death triggered by targeted accumulation of Cu in mitochondria that drives lipoylated TCA cycle enzyme aggregation via direct Cu binding.Tsvetkov et al. (2022) discovered a new form of cell death triggered by targeted accumulation of Cu in mitocho...

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Bibliographic Details
Published in:Molecular cell Vol. 82; no. 10; p. 1786
Main Authors: Cobine, Paul A, Brady, Donita C
Format: Journal Article
Language:English
Published: United States 19.05.2022
Subjects:
Apoptosis
Cell Death
Copper - metabolism
Lipoylation
Mitochondria - metabolism
ISSN:1097-4164, 1097-4164
Online Access:Get more information
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Summary:Tsvetkov et al. (2022) discovered a new form of cell death triggered by targeted accumulation of Cu in mitochondria that drives lipoylated TCA cycle enzyme aggregation via direct Cu binding.Tsvetkov et al. (2022) discovered a new form of cell death triggered by targeted accumulation of Cu in mitochondria that drives lipoylated TCA cycle enzyme aggregation via direct Cu binding.
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ISSN:1097-4164
1097-4164
DOI:10.1016/j.molcel.2022.05.001