Cuproptosis: Cellular and molecular mechanisms underlying copper-induced cell death

Tsvetkov et al. (2022) discovered a new form of cell death triggered by targeted accumulation of Cu in mitochondria that drives lipoylated TCA cycle enzyme aggregation via direct Cu binding.Tsvetkov et al. (2022) discovered a new form of cell death triggered by targeted accumulation of Cu in mitocho...

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Published in:Molecular cell Vol. 82; no. 10; p. 1786
Main Authors: Cobine, Paul A, Brady, Donita C
Format: Journal Article
Language:English
Published: United States 19.05.2022
Subjects:
Apoptosis
Cell Death
Copper - metabolism
Lipoylation
Mitochondria - metabolism
ISSN:1097-4164, 1097-4164
Online Access:Get more information
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Abstract Tsvetkov et al. (2022) discovered a new form of cell death triggered by targeted accumulation of Cu in mitochondria that drives lipoylated TCA cycle enzyme aggregation via direct Cu binding.Tsvetkov et al. (2022) discovered a new form of cell death triggered by targeted accumulation of Cu in mitochondria that drives lipoylated TCA cycle enzyme aggregation via direct Cu binding.
AbstractList Tsvetkov et al. (2022) discovered a new form of cell death triggered by targeted accumulation of Cu in mitochondria that drives lipoylated TCA cycle enzyme aggregation via direct Cu binding.
Tsvetkov et al. (2022) discovered a new form of cell death triggered by targeted accumulation of Cu in mitochondria that drives lipoylated TCA cycle enzyme aggregation via direct Cu binding.Tsvetkov et al. (2022) discovered a new form of cell death triggered by targeted accumulation of Cu in mitochondria that drives lipoylated TCA cycle enzyme aggregation via direct Cu binding.
Author Cobine, Paul A
Brady, Donita C
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  givenname: Donita C
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  email: bradyd@pennmedicine.upenn.edu
  organization: Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: bradyd@pennmedicine.upenn.edu
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References 35298263 - Science. 2022 Mar 18;375(6586):1254-1261. doi: 10.1126/science.abf0529.
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Snippet Tsvetkov et al. (2022) discovered a new form of cell death triggered by targeted accumulation of Cu in mitochondria that drives lipoylated TCA cycle enzyme...
Tsvetkov et al. (2022) discovered a new form of cell death triggered by targeted accumulation of Cu in mitochondria that drives lipoylated TCA cycle enzyme...
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SubjectTerms Apoptosis
Cell Death
Copper - metabolism
Lipoylation
Mitochondria - metabolism
Title Cuproptosis: Cellular and molecular mechanisms underlying copper-induced cell death
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