Cuproptosis: Cellular and molecular mechanisms underlying copper-induced cell death

Tsvetkov et al. (2022) discovered a new form of cell death triggered by targeted accumulation of Cu in mitochondria that drives lipoylated TCA cycle enzyme aggregation via direct Cu binding.Tsvetkov et al. (2022) discovered a new form of cell death triggered by targeted accumulation of Cu in mitocho...

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Veröffentlicht in:Molecular cell Jg. 82; H. 10; S. 1786
Hauptverfasser: Cobine, Paul A, Brady, Donita C
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 19.05.2022
Schlagworte:
Apoptosis
Cell Death
Copper - metabolism
Lipoylation
Mitochondria - metabolism
ISSN:1097-4164, 1097-4164
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Zusammenfassung:Tsvetkov et al. (2022) discovered a new form of cell death triggered by targeted accumulation of Cu in mitochondria that drives lipoylated TCA cycle enzyme aggregation via direct Cu binding.Tsvetkov et al. (2022) discovered a new form of cell death triggered by targeted accumulation of Cu in mitochondria that drives lipoylated TCA cycle enzyme aggregation via direct Cu binding.
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ISSN:1097-4164
1097-4164
DOI:10.1016/j.molcel.2022.05.001