Use of T-SPOT.TB in latent tuberculosis infection diagnosis in general and immunosuppressed populations

Immunosuppressed patients have a nine-fold greater risk of developing active tuberculosis (TB) disease given the latent TB infection than the general population. Few data are available on the predictivity of T-SPOT.TB in immunosuppressed patients. We had a T-SPOT.TB determination and a TST from 197...

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Published in:The New microbiologica Vol. 30; no. 3; p. 286
Main Authors: Piana, Federica, Ruffo Codecasa, Luigi, Baldan, Rossella, Miotto, Paolo, Ferrarese, Maurizio, Cirillo, Daniela Maria
Format: Journal Article
Language:English
Published: Italy 01.07.2007
Subjects:
Bacterial Proteins - immunology
Bacterial Proteins - metabolism
Bacteriological Techniques
Carrier State - diagnosis
Hematologic Diseases - immunology
Humans
Immunocompetence
Immunocompromised Host
Interferon-gamma - biosynthesis
Interferon-gamma - immunology
Logistic Models
Mycobacterium tuberculosis - metabolism
Peptides - immunology
Reagent Kits, Diagnostic
Sensitivity and Specificity
Species Specificity
T-Lymphocytes - immunology
Tuberculosis - diagnosis
ISSN:1121-7138
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Summary:Immunosuppressed patients have a nine-fold greater risk of developing active tuberculosis (TB) disease given the latent TB infection than the general population. Few data are available on the predictivity of T-SPOT.TB in immunosuppressed patients. We had a T-SPOT.TB determination and a TST from 197 immunosuppressed haematological patients and 324 community contacts of infectious TB cases. In the general population, TST was positive in 275 (84.9%), T-SPOT.TB in 167 (51.5%) (p < 0.0001). In immunosuppressed patients, TST was positive in 34 (17.3%), T-SPOT.TB in 70 (35.5%). T-SPOT.TB is not influenced by immunosuppression and even an indeterminate result may yield useful information on patient's anergy.
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ISSN:1121-7138