Principles and clinical applications of liquid chromatography — tandem mass spectrometry for the determination of adrenal and gonadal steroid hormones

Liquid-chromatography — tandem mass spectrometry (LC-MS/MS) is becoming the method of choice for clinical steroid analysis. In most instances, it has the advantage of higher sensitivity, better reproducibility and greater specificity than commercial immunoassay techniques. The method requires only m...

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Vydáno v:	Journal of endocrinological investigation Ročník 34; číslo 9; s. 702 - 708
Hlavní autoři:	Kulle, A. E., Welzel, M., Holterhus, P.-M., Riepe, F. G.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Cham Springer International Publishing 01.10.2011
Témata:	Adrenal Gland Diseases - diagnosis Adrenal Glands - chemistry Chromatography, Liquid - economics Chromatography, Liquid - instrumentation Chromatography, Liquid - methods Endocrinology Endocrinology - economics Endocrinology - methods Gonadal Steroid Hormones - analysis Humans Immunoassay - economics Immunoassay - instrumentation Immunoassay - methods Medicine Medicine & Public Health Metabolic Diseases Molecular Structure Reference Values Sensitivity and Specificity Short Review Steroids - analysis Tandem Mass Spectrometry - economics Tandem Mass Spectrometry - instrumentation Tandem Mass Spectrometry - methods clinical gonadal tandem mass spectrometry application Adrenal steroid
ISSN:	0391-4097, 1720-8386, 1720-8386
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Abstract	Liquid-chromatography — tandem mass spectrometry (LC-MS/MS) is becoming the method of choice for clinical steroid analysis. In most instances, it has the advantage of higher sensitivity, better reproducibility and greater specificity than commercial immunoassay techniques. The method requires only minimal sample preparation and a small sample volume. Furthermore, it has the potential to analyze multiple steroids simultaneously. Modern instruments guarantee high throughput, allowing an affordable price for the individual assay. All this makes LC-MS/MS an attractive method for use in a clinical setting. Reliable reference ranges for the detected analytes are the pre-requisite for their clinical use. If these are available, LC-MS/MS can find application in congenital disorders of steroid metabolism, such as congenital adrenal hyperplasia, disorders of sex development and disorders of salt homeostasis, as well as in acquired disorders of steroid metabolism, such as primary aldosteronism, Cushing’s disease, Addison’s disease, and hyperandrogenemia, as well as in psychiatric disease states such as depression or anxiety disorders. The principles of LC-MS/MS for steroid measurement, the pros and cons of LC-MS/MS compared with conventional immunoassays and the possible applications in clinical routine, with a special focus on pediatric endocrinology needs, are discussed here.
AbstractList	Liquid-chromatography - tandem mass spectrometry (LC-MS/MS) is becoming the method of choice for clinical steroid analysis. In most instances, it has the advantage of higher sensitivity, better reproducibility and greater specificity than commercial immunoassay techniques. The method requires only minimal sample preparation and a small sample volume. Furthermore, it has the potential to analyze multiple steroids simultaneously. Modern instruments guarantee high throughput, allowing an affordable price for the individual assay. All this makes LC-MS/MS an attractive method for use in a clinical setting. Reliable reference ranges for the detected analytes are the pre-requisite for their clinical use. If these are available, LC-MS/MS can find application in congenital disorders of steroid metabolism, such as congenital adrenal hyperplasia, disorders of sex development and disorders of salt homeostasis, as well as in acquired disorders of steroid metabolism, such as primary aldosteronism, Cushing's disease, Addison's disease, and hyperandrogenemia, as well as in psychiatric disease states such as depression or anxiety disorders. The principles of LC-MS/MS for steroid measurement, the pros and cons of LC-MS/MS compared with conventional immunoassays and the possible applications in clinical routine, with a special focus on pediatric endocrinology needs, are discussed here. Liquid-chromatography - tandem mass spectrometry (LC-MS/MS) is becoming the method of choice for clinical steroid analysis. In most instances, it has the advantage of higher sensitivity, better reproducibility and greater specificity than commercial immunoassay techniques. The method requires only minimal sample preparation and a small sample volume. Furthermore, it has the potential to analyze multiple steroids simultaneously. Modern instruments guarantee high throughput, allowing an affordable price for the individual assay. All this makes LC-MS/MS an attractive method for use in a clinical setting. Reliable reference ranges for the detected analytes are the pre-requisite for their clinical use. If these are available, LC-MS/MS can find application in congenital disorders of steroid metabolism, such as congenital adrenal hyperplasia, disorders of sex development and disorders of salt homeostasis, as well as in acquired disorders of steroid metabolism, such as primary aldosteronism, Cushing's disease, Addison's disease, and hyperandrogenemia, as well as in psychiatric disease states such as depression or anxiety disorders. The principles of LC-MS/MS for steroid measurement, the pros and cons of LC-MS/MS compared with conventional immunoassays and the possible applications in clinical routine, with a special focus on pediatric endocrinology needs, are discussed here.Liquid-chromatography - tandem mass spectrometry (LC-MS/MS) is becoming the method of choice for clinical steroid analysis. In most instances, it has the advantage of higher sensitivity, better reproducibility and greater specificity than commercial immunoassay techniques. The method requires only minimal sample preparation and a small sample volume. Furthermore, it has the potential to analyze multiple steroids simultaneously. Modern instruments guarantee high throughput, allowing an affordable price for the individual assay. All this makes LC-MS/MS an attractive method for use in a clinical setting. Reliable reference ranges for the detected analytes are the pre-requisite for their clinical use. If these are available, LC-MS/MS can find application in congenital disorders of steroid metabolism, such as congenital adrenal hyperplasia, disorders of sex development and disorders of salt homeostasis, as well as in acquired disorders of steroid metabolism, such as primary aldosteronism, Cushing's disease, Addison's disease, and hyperandrogenemia, as well as in psychiatric disease states such as depression or anxiety disorders. The principles of LC-MS/MS for steroid measurement, the pros and cons of LC-MS/MS compared with conventional immunoassays and the possible applications in clinical routine, with a special focus on pediatric endocrinology needs, are discussed here.
Author	Riepe, F. G. Kulle, A. E. Welzel, M. Holterhus, P.-M.
Author_xml	– sequence: 1 givenname: A. E. surname: Kulle fullname: Kulle, A. E. organization: Dept. of Pediatrics, Div. of Pediatric Endocrinology and Diabetes, University Hospital Schleswig-Holstein, Christian-Albrechts University of Kiel – sequence: 2 givenname: M. surname: Welzel fullname: Welzel, M. organization: Dept. of Pediatrics, Div. of Pediatric Endocrinology and Diabetes, University Hospital Schleswig-Holstein, Christian-Albrechts University of Kiel – sequence: 3 givenname: P.-M. surname: Holterhus fullname: Holterhus, P.-M. organization: Dept. of Pediatrics, Div. of Pediatric Endocrinology and Diabetes, University Hospital Schleswig-Holstein, Christian-Albrechts University of Kiel – sequence: 4 givenname: F. G. surname: Riepe fullname: Riepe, F. G. email: friepe@pediatrics.uni-kiel.de organization: Dept. of Pediatrics, Div. of Pediatric Endocrinology and Diabetes, University Hospital Schleswig-Holstein, Christian-Albrechts University of Kiel
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Snippet	Liquid-chromatography — tandem mass spectrometry (LC-MS/MS) is becoming the method of choice for clinical steroid analysis. In most instances, it has the... Liquid-chromatography - tandem mass spectrometry (LC-MS/MS) is becoming the method of choice for clinical steroid analysis. In most instances, it has the...
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SubjectTerms	Adrenal Gland Diseases - diagnosis Adrenal Glands - chemistry Chromatography, Liquid - economics Chromatography, Liquid - instrumentation Chromatography, Liquid - methods Endocrinology Endocrinology - economics Endocrinology - methods Gonadal Steroid Hormones - analysis Humans Immunoassay - economics Immunoassay - instrumentation Immunoassay - methods Medicine Medicine & Public Health Metabolic Diseases Molecular Structure Reference Values Sensitivity and Specificity Short Review Steroids - analysis Tandem Mass Spectrometry - economics Tandem Mass Spectrometry - instrumentation Tandem Mass Spectrometry - methods
Title	Principles and clinical applications of liquid chromatography — tandem mass spectrometry for the determination of adrenal and gonadal steroid hormones
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