Design and Cytotoxicity Evaluation of a Cancer-targeting Immunotoxin Based on a Camelid Nanobody-PE Fusion Protein

Developing effective targeted treatment approaches to overcome drug resistance remains a crucial goal in cancer research. Immunotoxins have dual functionality in cancer detection and targeted therapy. This study aimed to engineer a recombinant chimeric fusion protein by combining a nanobody-targetin...

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Bibliographic Details
Published in:	Iranian journal of immunology Vol. 21; no. 4; p. 302
Main Authors:	Khoshbakht, Mona, Forghanifard, Mohammad Mahdi, Aghamollaei, Hossein, Amani, Jafar
Format:	Journal Article
Language:	English
Published:	Iran Shiraz Institute for Cancer Research 31.12.2024
Subjects:	ADP Ribose Transferases - genetics ADP Ribose Transferases - immunology Animals Annexin V Apoptosis Apoptosis - drug effects Bacterial Toxins - immunology Breast Neoplasms - immunology Breast Neoplasms - therapy Camelus Cancer Cell Line, Tumor Cell proliferation Cytotoxicity Drug resistance Endoplasmic Reticulum Chaperone BiP Enzyme-linked immunosorbent assay Exotoxins Exotoxins - immunology Exotoxins - pharmacology Female Flow cytometry Fusion protein Heat-Shock Proteins - genetics Heat-Shock Proteins - immunology HEK293 Cells Humans Immunotoxins Immunotoxins - pharmacology Internalization MCF-7 Cells Nanobodies Neoplasms - immunology Neoplasms - therapy Proteins Pseudomonas aeruginosa Exotoxin A Recombinant Fusion Proteins - pharmacology Single-Domain Antibodies - immunology Single-Domain Antibodies - pharmacology Tumor cell lines Virulence Factors - immunology Western blotting GRP78 Nanobody Recombinant Protein Exotoxin Breast Cancer
ISSN:	1735-1383, 1735-367X, 1735-367X
Online Access:	Get full text
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