A novel host defense system of airways is defective in cystic fibrosis

The respiratory tract is constantly exposed to airborne microorganisms. Nevertheless, normal airways remain sterile without recruiting phagocytes. This innate immune activity has been attributed to mucociliary clearance and antimicrobial polypeptides of airway surface liquid. Defective airway immuni...

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Bibliographic Details
Published in:	American journal of respiratory and critical care medicine Vol. 175; no. 2; pp. 174 - 183
Main Authors:	Moskwa, Patryk, Lorentzen, Daniel, Excoffon, Katherine J D A, Zabner, Joseph, McCray, Jr, Paul B, Nauseef, William M, Dupuy, Corinne, Bánfi, Botond
Format:	Journal Article
Language:	English
Published:	United States American Thoracic Society 15.01.2007
Subjects:	Acids Animals Bacteria Cattle Cells, Cultured Cystic fibrosis Cystic Fibrosis - enzymology Cystic Fibrosis - immunology Cystic Fibrosis - microbiology D. Cystic Fibrosis Dual Oxidases Enzymes Flavoproteins - analysis Flavoproteins - genetics Flavoproteins - metabolism Humans Hydrogen Peroxide - metabolism Immunity, Innate - genetics Immunity, Mucosal Lactoperoxidase - analysis Lactoperoxidase - genetics Lactoperoxidase - metabolism Lung Diseases - enzymology Lung Diseases - immunology Lung Diseases - microbiology Mutation Polypeptides Pseudomonas aeruginosa - immunology Rats Reactive Oxygen Species - metabolism Respiratory Mucosa - enzymology Respiratory Mucosa - immunology Respiratory Mucosa - microbiology RNA, Small Interfering - pharmacology Staphylococcus aureus - immunology Thiocyanates - metabolism Trachea - cytology Trachea - immunology Trachea - microbiology
ISSN:	1073-449X, 1535-4970
Online Access:	Get full text
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