Insight Into the Role of Long Noncoding RNA in Cancer Development and Progression

Long noncoding RNA (LncRNA) is a large class of RNA molecules with size larger than 200 nucleotides. They exhibit cellular functions although having no protein-coding capability. Accumulating evidence suggests that long noncoding RNA play crucial roles in cancer biology. Studies showed that deregula...

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Bibliographic Details
Published in:International review of cell and molecular biology Vol. 326; pp. 33 - 65
Main Authors: Li, C H, Chen, Y
Format: Journal Article
Language:English
Published: Netherlands 2016
Subjects:
Animals
Carcinogenesis
Disease Progression
Female
Humans
Male
Neoplasms - metabolism
RNA, Long Noncoding
long noncoding RNA
cancer stem cell
carcinogenesis
cancer development and progression
ISSN:1937-6448
Online Access:Get more information
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Summary:Long noncoding RNA (LncRNA) is a large class of RNA molecules with size larger than 200 nucleotides. They exhibit cellular functions although having no protein-coding capability. Accumulating evidence suggests that long noncoding RNA play crucial roles in cancer biology. Studies showed that deregulation of lncRNA was frequently observed in various types of cancers which contributed heavily to malignant phenotypical changes. Aberration of lncRNA can be induced by a number of factors such as dysregulated signaling pathway, response to catastrophic effect, viral infection, and contact with carcinogens. Meanwhile, alterations of lncRNA expression or function drive subsequent malignant development such as cell transformation or acquisition of stemness characteristics. Here, we give perspectives on recent findings on the involvement of lncRNAs in carcinogenesis and response to adverse tumor environment. Then, we discuss the role of lncRNAs in cancer stem cell which is an important model of cancer emergence. Last, we provide insight on the potential of lncRNAs in modulating environment favorable of cancer development and progression, and evaluate the diagnostic and prognostic value of lncRNAs in cancer management.
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ISSN:1937-6448
DOI:10.1016/bs.ircmb.2016.04.001