A 12-week clinical study assessing the clinical effects on plaque metabolism of a dentifrice containing 1.5% arginine, an insoluble calcium compound and 1,450 ppm fluoride

To evaluate the clinical effect on plaque metabolism of a dentifrice containing 1.5% arginine, an insoluble calcium compound and 1,450 ppm fluoride compared to a commercially available dentifrice containing 1,450 ppm fluoride in a silica base. A 12-week, parallel, randomized, double-blind study usin...

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Bibliographic Details
Published in:American journal of dentistry Vol. 27; no. 2; p. 100
Main Authors: Santarpia, 3rd, R Peter, Lavender, Stacey, Gittins, Elizabeth, Vandeven, Mark, Cummins, Diane, Sullivan, Richard
Format: Journal Article
Language:English
Published: United States 01.04.2014
Subjects:
Adult
Ammonia - analysis
Arginine - therapeutic use
Calcium Phosphates - therapeutic use
Cariogenic Agents - pharmacology
Cariostatic Agents - therapeutic use
Dental Plaque - chemistry
Dental Plaque - metabolism
Dentifrices - therapeutic use
Double-Blind Method
Female
Fluorides - therapeutic use
Follow-Up Studies
Humans
Hydrogen-Ion Concentration
Lactic Acid - analysis
Male
Middle Aged
Phosphates - therapeutic use
Silicic Acid - therapeutic use
Sodium Fluoride - therapeutic use
Sucrose - pharmacology
Toothpastes - therapeutic use
Young Adult
ISSN:0894-8275
Online Access:Get more information
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Summary:To evaluate the clinical effect on plaque metabolism of a dentifrice containing 1.5% arginine, an insoluble calcium compound and 1,450 ppm fluoride compared to a commercially available dentifrice containing 1,450 ppm fluoride in a silica base. A 12-week, parallel, randomized, double-blind study using 48 subjects was conducted at the Colgate-Palmolive Technology Center (Piscataway, NJ, USA). One group used a test dentifrice containing 1.5% arginine, an insoluble calcium compound and 1,450 ppm fluoride as sodium monofluorophosphate (MFP), and the other group used a commercial silica dentifrice with 1,450 ppm fluoride as sodium fluoride (NaF) as a control. Plaque metabolism analyses were conducted at baseline and after 2, 4, 6, 8, and 12 weeks of assigned product use. The plaque analyses included pH measurements before and after a sucrose rinse, ammonia production and lactic acid production. Subjects using the test dentifrice had significantly higher plaque pH values before (P< or = 0.01) and after (P< or = 0.045) a sucrose challenge than those using the commercially available control dentifrice. Subjects using the test dentifrice also produced higher levels of ammonia and lower levels of lactic acid compared to subjects using the control dentifrice.
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ISSN:0894-8275