Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4(CRBN.)

Cereblon (CRBN), the molecular target of lenalidomide and pomalidomide, is a substrate receptor of the cullin ring E3 ubiquitin ligase complex, CRL4(CRBN) . T cell co-stimulation by lenalidomide or pomalidomide is cereblon dependent: however, the CRL4(CRBN) substrates responsible for T cell co-stimu...

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Bibliographic Details
Published in:	British journal of haematology Vol. 164; no. 6; p. 811
Main Authors:	Gandhi, Anita K, Kang, Jian, Havens, Courtney G, Conklin, Thomas, Ning, Yuhong, Wu, Lei, Ito, Takumi, Ando, Hideki, Waldman, Michelle F, Thakurta, Anjan, Klippel, Anke, Handa, Hiroshi, Daniel, Thomas O, Schafer, Peter H, Chopra, Rajesh
Format:	Journal Article
Language:	English
Published:	England 01.03.2014
Subjects:	Adaptor Proteins, Signal Transducing Angiogenesis Inhibitors - pharmacology Humans Ikaros Transcription Factor - genetics Ikaros Transcription Factor - metabolism Immunologic Factors - pharmacology Lenalidomide Peptide Hydrolases - genetics Peptide Hydrolases - metabolism Proteasome Endopeptidase Complex - genetics Proteasome Endopeptidase Complex - metabolism T-Lymphocytes - drug effects T-Lymphocytes - metabolism Thalidomide - analogs & derivatives Thalidomide - pharmacology Transcription Factors - genetics Transcription Factors - metabolism Transfection Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism Ubiquitination lenalidomide Cereblon Ikaros pomalidomide Aiolos
ISSN:	1365-2141, 1365-2141
Online Access:	Get full text
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