APOE4 homozygozity represents a distinct genetic form of Alzheimer's disease

This study aimed to evaluate the impact of APOE4 homozygosity on Alzheimer's disease (AD) by examining its clinical, pathological and biomarker changes to see whether APOE4 homozygotes constitute a distinct, genetically determined form of AD. Data from the National Alzheimer's Coordinating...

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Bibliographic Details
Published in:	Nature medicine Vol. 30; no. 5; p. 1284
Main Authors:	Fortea, Juan, Pegueroles, Jordi, Alcolea, Daniel, Belbin, Olivia, Dols-Icardo, Oriol, Vaqué-Alcázar, Lídia, Videla, Laura, Gispert, Juan Domingo, Suárez-Calvet, Marc, Johnson, Sterling C, Sperling, Reisa, Bejanin, Alexandre, Lleó, Alberto, Montal, Víctor
Format:	Journal Article
Language:	English
Published:	United States 01.05.2024
Subjects:	Age of Onset Aged Aged, 80 and over Alzheimer Disease - cerebrospinal fluid Alzheimer Disease - diagnostic imaging Alzheimer Disease - genetics Alzheimer Disease - pathology Amyloid - genetics Amyloid - metabolism Amyloid beta-Peptides - cerebrospinal fluid Amyloid beta-Peptides - genetics Amyloid beta-Peptides - metabolism Apolipoprotein E3 - genetics Apolipoprotein E4 - genetics Biomarkers - cerebrospinal fluid Cohort Studies Female Homozygote Humans Male Middle Aged Positron-Emission Tomography tau Proteins - cerebrospinal fluid tau Proteins - genetics
ISSN:	1546-170X, 1546-170X
Online Access:	Get full text
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