APOE4 homozygozity represents a distinct genetic form of Alzheimer's disease

This study aimed to evaluate the impact of APOE4 homozygosity on Alzheimer's disease (AD) by examining its clinical, pathological and biomarker changes to see whether APOE4 homozygotes constitute a distinct, genetically determined form of AD. Data from the National Alzheimer's Coordinating...

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Veröffentlicht in:	Nature medicine Jg. 30; H. 5; S. 1284
Hauptverfasser:	Fortea, Juan, Pegueroles, Jordi, Alcolea, Daniel, Belbin, Olivia, Dols-Icardo, Oriol, Vaqué-Alcázar, Lídia, Videla, Laura, Gispert, Juan Domingo, Suárez-Calvet, Marc, Johnson, Sterling C, Sperling, Reisa, Bejanin, Alexandre, Lleó, Alberto, Montal, Víctor
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.05.2024
Schlagworte:	Age of Onset Aged Aged, 80 and over Alzheimer Disease - cerebrospinal fluid Alzheimer Disease - diagnostic imaging Alzheimer Disease - genetics Alzheimer Disease - pathology Amyloid - genetics Amyloid - metabolism Amyloid beta-Peptides - cerebrospinal fluid Amyloid beta-Peptides - genetics Amyloid beta-Peptides - metabolism Apolipoprotein E3 - genetics Apolipoprotein E4 - genetics Biomarkers - cerebrospinal fluid Cohort Studies Female Homozygote Humans Male Middle Aged Positron-Emission Tomography tau Proteins - cerebrospinal fluid tau Proteins - genetics
ISSN:	1546-170X, 1546-170X
Online-Zugang:	Volltext
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