Geographic Atrophy Phenotypes in Subjects of Different Ethnicity: Asia-Pacific Ocular Imaging Society Work Group Report 3
To characterize geographic atrophy (GA) and evaluate differences between Asians and non-Asians. Multicenter, retrospective case series. Subjects aged ≥ 50 years with GA secondary to age-related macular degeneration in the absence of neovascularization in the study eye and follow-up of ≥ 2 years. The...
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| Vydané v: | Ophthalmology retina Ročník 7; číslo 7; s. 593 |
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01.07.2023
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| Abstract | To characterize geographic atrophy (GA) and evaluate differences between Asians and non-Asians.
Multicenter, retrospective case series.
Subjects aged ≥ 50 years with GA secondary to age-related macular degeneration in the absence of neovascularization in the study eye and follow-up of ≥ 2 years.
The GA lesion characterized at baseline and last follow-up based on multimodal imaging (fundus autofluorescence [FAF], near infrared [NIR], and spectral domain-OCT). Patients were grouped as either Asian or non-Asian.
Comparison of (1) phenotypes of GA lesions (size, foveal involvement, number of foci, drusen background, and choroid background) and (2) growth rates of GA.
A total of 144 patients (169 eyes) with distribution of 50.9% Asians and 49.1% non-Asians. The age and sex were similar between Asians and non-Asians (Asians: mean age, 77.2 ± 10.1 years, 47.9% female; non-Asians: mean age, 79.7 ± 8.4 years, 58.7% female). Asians exhibited thicker choroids (167 ± 74 versus [vs.] 134 ± 56 μm; P < 0.01) and lower prevalence of drusen (40.7% vs. 66.3%; P < 0.01). At baseline, the GA area was smaller in Asians vs. non-Asians (NIR, 3.7 ± 4.6 vs. 6.3 ± 6.8 mm
; P = 0.01: FAF, 2.4 ± 3.4 vs. 8.4 ± 9.6 mm
; P < 0.01). Asians had fewer GA foci (1.7 ± 1.3 vs. 2.7 ± 2.2; P < 0.01) compared to non-Asians. The proportion with diffused or banded FAF junctional zone pattern was similar between Asians and non-Asians (44.2% vs. 60.2%; P = 0.20). Asians had a slower GA lesion growth rate than non-Asians (NIR, 0.7 vs. 1.9 mm
/year; P < 0.01: FAF, 0.3 vs. 2.0 mm
/year; P < 0.01: NIR, 0.2 vs. 0.4 mm/year; P < 0.01 square root transformed: FAF, 0.1 vs. 0.3 mm/year; P < 0.01 square root transformed). The factors associated with GA lesion growth rate are (from the highest effect size) ethnicity, junctional zone FAF pattern, baseline GA area, and number of GA foci. Higher GA lesion growth rate was observed in both Asian and non-Asian subgroups, with drusen or lesion size and FAF patterns meeting inclusion criteria of recent therapeutic trials, but growth rate remained significantly slower in Asians. Eyes with baseline lesion ≥ 5 mm
showed the highest growth rate, and the difference between ethnicities was no longer significant (2.6 vs. 3.3 mm
/year; P = 0.14).
There are differences in GA lesion phenotype, associated features, and growth rate between Asians and non-Asian subjects.
Proprietary or commercial disclosure may be found after the references. |
|---|---|
| AbstractList | To characterize geographic atrophy (GA) and evaluate differences between Asians and non-Asians.
Multicenter, retrospective case series.
Subjects aged ≥ 50 years with GA secondary to age-related macular degeneration in the absence of neovascularization in the study eye and follow-up of ≥ 2 years.
The GA lesion characterized at baseline and last follow-up based on multimodal imaging (fundus autofluorescence [FAF], near infrared [NIR], and spectral domain-OCT). Patients were grouped as either Asian or non-Asian.
Comparison of (1) phenotypes of GA lesions (size, foveal involvement, number of foci, drusen background, and choroid background) and (2) growth rates of GA.
A total of 144 patients (169 eyes) with distribution of 50.9% Asians and 49.1% non-Asians. The age and sex were similar between Asians and non-Asians (Asians: mean age, 77.2 ± 10.1 years, 47.9% female; non-Asians: mean age, 79.7 ± 8.4 years, 58.7% female). Asians exhibited thicker choroids (167 ± 74 versus [vs.] 134 ± 56 μm; P < 0.01) and lower prevalence of drusen (40.7% vs. 66.3%; P < 0.01). At baseline, the GA area was smaller in Asians vs. non-Asians (NIR, 3.7 ± 4.6 vs. 6.3 ± 6.8 mm
; P = 0.01: FAF, 2.4 ± 3.4 vs. 8.4 ± 9.6 mm
; P < 0.01). Asians had fewer GA foci (1.7 ± 1.3 vs. 2.7 ± 2.2; P < 0.01) compared to non-Asians. The proportion with diffused or banded FAF junctional zone pattern was similar between Asians and non-Asians (44.2% vs. 60.2%; P = 0.20). Asians had a slower GA lesion growth rate than non-Asians (NIR, 0.7 vs. 1.9 mm
/year; P < 0.01: FAF, 0.3 vs. 2.0 mm
/year; P < 0.01: NIR, 0.2 vs. 0.4 mm/year; P < 0.01 square root transformed: FAF, 0.1 vs. 0.3 mm/year; P < 0.01 square root transformed). The factors associated with GA lesion growth rate are (from the highest effect size) ethnicity, junctional zone FAF pattern, baseline GA area, and number of GA foci. Higher GA lesion growth rate was observed in both Asian and non-Asian subgroups, with drusen or lesion size and FAF patterns meeting inclusion criteria of recent therapeutic trials, but growth rate remained significantly slower in Asians. Eyes with baseline lesion ≥ 5 mm
showed the highest growth rate, and the difference between ethnicities was no longer significant (2.6 vs. 3.3 mm
/year; P = 0.14).
There are differences in GA lesion phenotype, associated features, and growth rate between Asians and non-Asian subjects.
Proprietary or commercial disclosure may be found after the references. To characterize geographic atrophy (GA) and evaluate differences between Asians and non-Asians.OBJECTIVETo characterize geographic atrophy (GA) and evaluate differences between Asians and non-Asians.Multicenter, retrospective case series.DESIGNMulticenter, retrospective case series.Subjects aged ≥ 50 years with GA secondary to age-related macular degeneration in the absence of neovascularization in the study eye and follow-up of ≥ 2 years.PARTICIPANTSSubjects aged ≥ 50 years with GA secondary to age-related macular degeneration in the absence of neovascularization in the study eye and follow-up of ≥ 2 years.The GA lesion characterized at baseline and last follow-up based on multimodal imaging (fundus autofluorescence [FAF], near infrared [NIR], and spectral domain-OCT). Patients were grouped as either Asian or non-Asian.METHODSThe GA lesion characterized at baseline and last follow-up based on multimodal imaging (fundus autofluorescence [FAF], near infrared [NIR], and spectral domain-OCT). Patients were grouped as either Asian or non-Asian.Comparison of (1) phenotypes of GA lesions (size, foveal involvement, number of foci, drusen background, and choroid background) and (2) growth rates of GA.MAIN OUTCOME MEASURESComparison of (1) phenotypes of GA lesions (size, foveal involvement, number of foci, drusen background, and choroid background) and (2) growth rates of GA.A total of 144 patients (169 eyes) with distribution of 50.9% Asians and 49.1% non-Asians. The age and sex were similar between Asians and non-Asians (Asians: mean age, 77.2 ± 10.1 years, 47.9% female; non-Asians: mean age, 79.7 ± 8.4 years, 58.7% female). Asians exhibited thicker choroids (167 ± 74 versus [vs.] 134 ± 56 μm; P < 0.01) and lower prevalence of drusen (40.7% vs. 66.3%; P < 0.01). At baseline, the GA area was smaller in Asians vs. non-Asians (NIR, 3.7 ± 4.6 vs. 6.3 ± 6.8 mm2; P = 0.01: FAF, 2.4 ± 3.4 vs. 8.4 ± 9.6 mm2; P < 0.01). Asians had fewer GA foci (1.7 ± 1.3 vs. 2.7 ± 2.2; P < 0.01) compared to non-Asians. The proportion with diffused or banded FAF junctional zone pattern was similar between Asians and non-Asians (44.2% vs. 60.2%; P = 0.20). Asians had a slower GA lesion growth rate than non-Asians (NIR, 0.7 vs. 1.9 mm2/year; P < 0.01: FAF, 0.3 vs. 2.0 mm2/year; P < 0.01: NIR, 0.2 vs. 0.4 mm/year; P < 0.01 square root transformed: FAF, 0.1 vs. 0.3 mm/year; P < 0.01 square root transformed). The factors associated with GA lesion growth rate are (from the highest effect size) ethnicity, junctional zone FAF pattern, baseline GA area, and number of GA foci. Higher GA lesion growth rate was observed in both Asian and non-Asian subgroups, with drusen or lesion size and FAF patterns meeting inclusion criteria of recent therapeutic trials, but growth rate remained significantly slower in Asians. Eyes with baseline lesion ≥ 5 mm2 showed the highest growth rate, and the difference between ethnicities was no longer significant (2.6 vs. 3.3 mm2/year; P = 0.14).RESULTSA total of 144 patients (169 eyes) with distribution of 50.9% Asians and 49.1% non-Asians. The age and sex were similar between Asians and non-Asians (Asians: mean age, 77.2 ± 10.1 years, 47.9% female; non-Asians: mean age, 79.7 ± 8.4 years, 58.7% female). Asians exhibited thicker choroids (167 ± 74 versus [vs.] 134 ± 56 μm; P < 0.01) and lower prevalence of drusen (40.7% vs. 66.3%; P < 0.01). At baseline, the GA area was smaller in Asians vs. non-Asians (NIR, 3.7 ± 4.6 vs. 6.3 ± 6.8 mm2; P = 0.01: FAF, 2.4 ± 3.4 vs. 8.4 ± 9.6 mm2; P < 0.01). Asians had fewer GA foci (1.7 ± 1.3 vs. 2.7 ± 2.2; P < 0.01) compared to non-Asians. The proportion with diffused or banded FAF junctional zone pattern was similar between Asians and non-Asians (44.2% vs. 60.2%; P = 0.20). Asians had a slower GA lesion growth rate than non-Asians (NIR, 0.7 vs. 1.9 mm2/year; P < 0.01: FAF, 0.3 vs. 2.0 mm2/year; P < 0.01: NIR, 0.2 vs. 0.4 mm/year; P < 0.01 square root transformed: FAF, 0.1 vs. 0.3 mm/year; P < 0.01 square root transformed). The factors associated with GA lesion growth rate are (from the highest effect size) ethnicity, junctional zone FAF pattern, baseline GA area, and number of GA foci. Higher GA lesion growth rate was observed in both Asian and non-Asian subgroups, with drusen or lesion size and FAF patterns meeting inclusion criteria of recent therapeutic trials, but growth rate remained significantly slower in Asians. Eyes with baseline lesion ≥ 5 mm2 showed the highest growth rate, and the difference between ethnicities was no longer significant (2.6 vs. 3.3 mm2/year; P = 0.14).There are differences in GA lesion phenotype, associated features, and growth rate between Asians and non-Asian subjects.CONCLUSIONSThere are differences in GA lesion phenotype, associated features, and growth rate between Asians and non-Asian subjects.Proprietary or commercial disclosure may be found after the references.FINANCIAL DISCLOSURE(S)Proprietary or commercial disclosure may be found after the references. |
| Author | Cheng, Mark F S Sadda, Srinivas R Fujimoto, Satoko Ruamviboonsuk, Paisan Chainakul, Methaphon Kim, Judy E Teo, Kelvin Y C Kokame, Gregg Lai, Timothy Y Y Gomi, Fumi Corradetti, Giulia Lee, Won Ki Amornpetchsathaporn, Anyarak Cheung, Chui Ming Gemmy |
| Author_xml | – sequence: 1 givenname: Kelvin Y C surname: Teo fullname: Teo, Kelvin Y C organization: Singapore Eye Research Institute, Singapore National Eye Center, Singapore; Duke-NUS Medical School, National University of Singapore, Singapore – sequence: 2 givenname: Satoko surname: Fujimoto fullname: Fujimoto, Satoko organization: Division of Ophthalmology, Department of Surgery, University of Hawaii School of Medicine, St. Honolulu, Hawaii; Hawaii Macula and Retina Institute, Aiea, Hawaii – sequence: 3 givenname: Srinivas R surname: Sadda fullname: Sadda, Srinivas R organization: Doheny Eye Institute, David Geffen, School of Medicine, University of California-Los Angeles, Los Angeles, California – sequence: 4 givenname: Gregg surname: Kokame fullname: Kokame, Gregg organization: Division of Ophthalmology, Department of Surgery, University of Hawaii School of Medicine, St. Honolulu, Hawaii; Hawaii Macula and Retina Institute, Aiea, Hawaii – sequence: 5 givenname: Fumi surname: Gomi fullname: Gomi, Fumi organization: Department of Ophthalmology, Hyogo College of Medicine, Hyogo, Japan – sequence: 6 givenname: Judy E surname: Kim fullname: Kim, Judy E organization: Department of Ophthalmology and Visual Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin – sequence: 7 givenname: Mark F S surname: Cheng fullname: Cheng, Mark F S organization: Singapore Eye Research Institute, Singapore National Eye Center, Singapore – sequence: 8 givenname: Giulia surname: Corradetti fullname: Corradetti, Giulia organization: Doheny Eye Institute, David Geffen, School of Medicine, University of California-Los Angeles, Los Angeles, California – sequence: 9 givenname: Anyarak surname: Amornpetchsathaporn fullname: Amornpetchsathaporn, Anyarak organization: Department of Ophthalmology, Rajavithi Hospital, Bangkok, Thailand – sequence: 10 givenname: Methaphon surname: Chainakul fullname: Chainakul, Methaphon organization: Department of Ophthalmology, Rajavithi Hospital, Bangkok, Thailand – sequence: 11 givenname: Won Ki surname: Lee fullname: Lee, Won Ki organization: Nune Eye Hospital, Seoul, South Korea – sequence: 12 givenname: Timothy Y Y surname: Lai fullname: Lai, Timothy Y Y organization: Department of Ophthalmology and Visual Sciences, the Chinese University of Hong Kong Hong Kong Eye Hospital, Hong Kong – sequence: 13 givenname: Paisan surname: Ruamviboonsuk fullname: Ruamviboonsuk, Paisan organization: Department of Ophthalmology, Rajavithi Hospital, Bangkok, Thailand – sequence: 14 givenname: Chui Ming Gemmy surname: Cheung fullname: Cheung, Chui Ming Gemmy email: gemmy.cheung.c.m@singhealth.com.sg organization: Singapore Eye Research Institute, Singapore National Eye Center, Singapore; Duke-NUS Medical School, National University of Singapore, Singapore. Electronic address: gemmy.cheung.c.m@singhealth.com.sg |
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| Keywords | Geographic atrophy Pseudodrusen Phenotype Dry AMD Asian |
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| Snippet | To characterize geographic atrophy (GA) and evaluate differences between Asians and non-Asians.
Multicenter, retrospective case series.
Subjects aged ≥ 50... To characterize geographic atrophy (GA) and evaluate differences between Asians and non-Asians.OBJECTIVETo characterize geographic atrophy (GA) and evaluate... |
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| Title | Geographic Atrophy Phenotypes in Subjects of Different Ethnicity: Asia-Pacific Ocular Imaging Society Work Group Report 3 |
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