BRAF(V600E) Mutation is Associated with Decreased Disease-Free Survival in Papillary Thyroid Cancer

The BRAF (V600E) mutation is a recognised molecular marker in papillary thyroid cancer (PTC), reported incidence from 30 to 80 %. BRAF(V600E) aberrantly activates the MAPK pathway, a central regulator of cell growth and proliferation. Previous studies have reported conflicting data regarding the imp...

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Bibliographic Details
Published in:	World journal of surgery Vol. 40; no. 7; p. 1618
Main Authors:	Fraser, S, Go, C, Aniss, A, Sidhu, S, Delbridge, L, Learoyd, D, Clifton-Bligh, R, Tacon, L, Tsang, V, Robinson, B, Gill, A J, Sywak, M
Format:	Journal Article
Language:	English
Published:	United States 01.07.2016
Subjects:	Ablation Techniques Adolescent Adult Aged Aged, 80 and over Biomarkers, Tumor - genetics Carcinoma - genetics Carcinoma - secondary Carcinoma - surgery Carcinoma, Papillary Child Cohort Studies Disease-Free Survival Female Humans Iodine Radioisotopes - therapeutic use Lymphatic Metastasis Male Middle Aged Mutation Neoplasm Recurrence, Local - genetics Proto-Oncogene Proteins B-raf - analysis Proto-Oncogene Proteins B-raf - genetics Thyroid Cancer, Papillary Thyroid Neoplasms - genetics Thyroid Neoplasms - pathology Thyroid Neoplasms - surgery Tumor Burden - genetics Young Adult
ISSN:	1432-2323, 1432-2323
Online Access:	Get full text
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