BRAF(V600E) Mutation is Associated with Decreased Disease-Free Survival in Papillary Thyroid Cancer

The BRAF (V600E) mutation is a recognised molecular marker in papillary thyroid cancer (PTC), reported incidence from 30 to 80 %. BRAF(V600E) aberrantly activates the MAPK pathway, a central regulator of cell growth and proliferation. Previous studies have reported conflicting data regarding the imp...

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Vydáno v:	World journal of surgery Ročník 40; číslo 7; s. 1618
Hlavní autoři:	Fraser, S, Go, C, Aniss, A, Sidhu, S, Delbridge, L, Learoyd, D, Clifton-Bligh, R, Tacon, L, Tsang, V, Robinson, B, Gill, A J, Sywak, M
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.07.2016
Témata:	Ablation Techniques Adolescent Adult Aged Aged, 80 and over Biomarkers, Tumor - genetics Carcinoma - genetics Carcinoma - secondary Carcinoma - surgery Carcinoma, Papillary Child Cohort Studies Disease-Free Survival Female Humans Iodine Radioisotopes - therapeutic use Lymphatic Metastasis Male Middle Aged Mutation Neoplasm Recurrence, Local - genetics Proto-Oncogene Proteins B-raf - analysis Proto-Oncogene Proteins B-raf - genetics Thyroid Cancer, Papillary Thyroid Neoplasms - genetics Thyroid Neoplasms - pathology Thyroid Neoplasms - surgery Tumor Burden - genetics Young Adult
ISSN:	1432-2323, 1432-2323
On-line přístup:	Získat plný text
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