Antiarrhythmic profile and endothelial action of novel decahydroquinoline derivatives

We tested antiarrhythmic and endothelial action of novel decahydroquinoline derivatives. Antiarrhythmic activity was analyzed using models of aconitine-, calcium chloride-, and adrenaline-induced arrhythmias in rats. Potency to induce nitric oxide (NO)-dependent coronary vasodilation was assessed in...

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Veröffentlicht in:	Polish journal of pharmacology Jg. 56; H. 6; S. 767
Hauptverfasser:	Kozlovski, Valery I, Vdovichenko, Vladimir P, Chlopicki, Stefan, Malchik, Sergey S, Praliyev, Kaldybek D, Zcilkibayev, Oral T
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Poland 01.11.2004
Schlagworte:	Aconitine - toxicity Animals Anti-Arrhythmia Agents - chemistry Anti-Arrhythmia Agents - pharmacology Arrhythmias, Cardiac - chemically induced Arrhythmias, Cardiac - drug therapy Calcium Chloride - toxicity Coronary Vessels - drug effects Epinephrine - toxicity Female Guinea Pigs Male Molecular Structure Nitric Oxide - metabolism Quinolines - chemistry Quinolines - pharmacology Rats Rats, Wistar Structure-Activity Relationship Vasodilation - drug effects
ISSN:	1230-6002
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